7ppp

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<StructureSection load='7ppp' size='340' side='right'caption='[[7ppp]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='7ppp' size='340' side='right'caption='[[7ppp]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7ppp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PPP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7ppp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PPP FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ppp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ppp OCA], [https://pdbe.org/7ppp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ppp RCSB], [https://www.ebi.ac.uk/pdbsum/7ppp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ppp ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ppp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ppp OCA], [https://pdbe.org/7ppp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ppp RCSB], [https://www.ebi.ac.uk/pdbsum/7ppp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ppp ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[[https://www.uniprot.org/uniprot/A0A5F9DAT3_RABIT A0A5F9DAT3_RABIT]]
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ZAD is a C4 zinc-coordinating domain often found at the N-terminus mostly of arthropodan transcription factors with multiple C2H2 zinc-finger domains involved in the regulation of chromosome architecture and promotor activity. ZADs predominantly form homodimers and have low primary sequence similarity. We obtained three crystal structures of the most phylogenetically distant Drosophila ZADs and structure of the only known ZAD-like domain from a mammalian protein (ZNF276). All ZAD structures demonstrate unity of the spatial fold as well as some unique structural features. The specific homodimerization of ZAD is primarily determined by the position and size of secondary structural elements and is further strengthened by a number of unique interactions between subunits. Structural comparison allowed for unraveling key sequence features underlying the similarity of the spatial fold. These features result in a broad variety of ZADs in Arthropod C2H2 proteins, allowing for the emergence of a wide range of highly specific homodimers.
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Structural insights into highly similar spatial organization of zinc-finger associated domains with a very low sequence similarity.,Bonchuk AN, Boyko KM, Nikolaeva AY, Burtseva AD, Popov VO, Georgiev PG Structure. 2022 Jul 7;30(7):1004-1015.e4. doi: 10.1016/j.str.2022.04.009. Epub, 2022 May 16. PMID:35580610<ref>PMID:35580610</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7ppp" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bonchuk, A N]]
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[[Category: Oryctolagus cuniculus]]
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[[Category: Boyko, K M]]
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[[Category: Bonchuk AN]]
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[[Category: Georgiev, P G]]
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[[Category: Boyko KM]]
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[[Category: Nikolaeva, A Y]]
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[[Category: Georgiev PG]]
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[[Category: Popov, V O]]
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[[Category: Nikolaeva AY]]
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[[Category: Dimerization]]
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[[Category: Popov VO]]
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[[Category: M1bp]]
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[[Category: Protein interaction]]
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[[Category: Transcription]]
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[[Category: Treble-cleft-like]]
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[[Category: Zad]]
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[[Category: Zinc binding]]
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[[Category: Zinc-finger associated domain]]
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Revision as of 05:25, 8 September 2022

Crystal structure of ZAD-domain of ZNF_276 protein from rabbit.

PDB ID 7ppp

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