7qcc

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==Williams-Beuren syndrome related methyltransferase WBSCR27 in apo-form==
==Williams-Beuren syndrome related methyltransferase WBSCR27 in apo-form==
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<StructureSection load='7qcc' size='340' side='right'caption='[[7qcc]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='7qcc' size='340' side='right'caption='[[7qcc]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7qcc]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QCC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7qcc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QCC FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qcc OCA], [https://pdbe.org/7qcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qcc RCSB], [https://www.ebi.ac.uk/pdbsum/7qcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qcc ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qcc OCA], [https://pdbe.org/7qcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qcc RCSB], [https://www.ebi.ac.uk/pdbsum/7qcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qcc ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[[https://www.uniprot.org/uniprot/Q8BGM4_MOUSE Q8BGM4_MOUSE]]
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Williams-Beuren syndrome (WBS) is a genetic disorder associated with the hemizygous deletion of several genes in chromosome 7, encoding 26 proteins. Malfunction of these proteins induce multisystemic failure in an organism. While biological functions of most proteins are more or less established, the one of methyltransferase WBSCR27 remains elusive. To find the substrate of methylation catalyzed by WBSCR27 we constructed mouse cell lines with a Wbscr27 gene knockout and studied the obtained cells using several molecular biology and mass spectrometry techniques. We attempted to pinpoint the methylation target among the RNAs and proteins, but in all cases neither a direct substrate has been identified nor the protein partners have been detected. To reveal the nature of the putative methylation substrate we determined the solution structure and studied the conformational dynamic properties of WBSCR27 in apo state and in complex with S-adenosyl-L-homocysteine (SAH). The protein core was found to form a canonical Rossman fold common for Class I methyltransferases. N-terminus of the protein and the beta6-beta7 loop were disordered in apo-form, but binding of SAH induced the transition of these fragments to a well-formed substrate binding site. Analyzing the structure of this binding site allows us to suggest potential substrates of WBSCR27 methylation to be probed in further research.
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Williams-Beuren Syndrome Related Methyltransferase WBSCR27: From Structure to Possible Function.,Mariasina SS, Chang CF, Navalayeu TL, Chugunova AA, Efimov SV, Zgoda VG, Ivlev VA, Dontsova OA, Sergiev PV, Polshakov VI Front Mol Biosci. 2022 Jun 15;9:865743. doi: 10.3389/fmolb.2022.865743., eCollection 2022. PMID:35782865<ref>PMID:35782865</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7qcc" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chang, C F]]
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[[Category: Mus musculus]]
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[[Category: Mariasina, S S]]
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[[Category: Chang C-F]]
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[[Category: Polshakov, V I]]
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[[Category: Mariasina SS]]
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[[Category: Class i methyltransferase]]
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[[Category: Polshakov VI]]
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[[Category: Rossmann fold]]
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[[Category: Sam-dependent methyltransferase]]
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[[Category: Transferase]]
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[[Category: Williams-beuren syndrome]]
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Revision as of 05:25, 8 September 2022

Williams-Beuren syndrome related methyltransferase WBSCR27 in apo-form

PDB ID 7qcc

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