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1ias

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[[Image:1ias.gif|left|200px]]
[[Image:1ias.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1ias |SIZE=350|CAPTION= <scene name='initialview01'>1ias</scene>, resolution 2.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1ias", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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{{STRUCTURE_1ias| PDB=1ias | SCENE= }}
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|RELATEDENTRY=[[1b6c|1b6c]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ias FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ias OCA], [http://www.ebi.ac.uk/pdbsum/1ias PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ias RCSB]</span>
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}}
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'''CYTOPLASMIC DOMAIN OF UNPHOSPHORYLATED TYPE I TGF-BETA RECEPTOR CRYSTALLIZED WITHOUT FKBP12'''
'''CYTOPLASMIC DOMAIN OF UNPHOSPHORYLATED TYPE I TGF-BETA RECEPTOR CRYSTALLIZED WITHOUT FKBP12'''
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[[Category: Massague, J.]]
[[Category: Massague, J.]]
[[Category: Muir, T W.]]
[[Category: Muir, T W.]]
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[[Category: gs region]]
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[[Category: Gs region]]
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[[Category: kinase]]
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[[Category: Kinase]]
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[[Category: tgf-beta receptor]]
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[[Category: Tgf-beta receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:46:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:17:08 2008''
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Revision as of 16:46, 2 May 2008

Image:1ias.gif

Template:STRUCTURE 1ias

CYTOPLASMIC DOMAIN OF UNPHOSPHORYLATED TYPE I TGF-BETA RECEPTOR CRYSTALLIZED WITHOUT FKBP12


Overview

The type I TGF beta receptor (T beta R-I) is activated by phosphorylation of the GS region, a conserved juxtamembrane segment located just N-terminal to the kinase domain. We have studied the molecular mechanism of receptor activation using a homogeneously tetraphosphorylated form of T beta R-I, prepared using protein semisynthesis. Phosphorylation of the GS region dramatically enhances the specificity of T beta R-I for the critical C-terminal serines of Smad2. In addition, tetraphosphorylated T beta R-I is bound specifically by Smad2 in a phosphorylation-dependent manner and is no longer recognized by the inhibitory protein FKBP12. Thus, phosphorylation activates T beta R-I by switching the GS region from a binding site for an inhibitor into a binding surface for substrate. Our observations suggest that phosphoserine/phosphothreonine-dependent localization is a key feature of the T beta R-I/Smad activation process.

About this Structure

1IAS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The TGF beta receptor activation process: an inhibitor- to substrate-binding switch., Huse M, Muir TW, Xu L, Chen YG, Kuriyan J, Massague J, Mol Cell. 2001 Sep;8(3):671-82. PMID:11583628 Page seeded by OCA on Fri May 2 19:46:53 2008

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