1iar

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1iar.jpg|left|200px]]
[[Image:1iar.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1iar |SIZE=350|CAPTION= <scene name='initialview01'>1iar</scene>, resolution 2.3&Aring;
+
The line below this paragraph, containing "STRUCTURE_1iar", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1iar| PDB=1iar | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iar OCA], [http://www.ebi.ac.uk/pdbsum/1iar PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1iar RCSB]</span>
+
-
}}
+
'''INTERLEUKIN-4 / RECEPTOR ALPHA CHAIN COMPLEX'''
'''INTERLEUKIN-4 / RECEPTOR ALPHA CHAIN COMPLEX'''
Line 28: Line 25:
[[Category: Reinemer, P.]]
[[Category: Reinemer, P.]]
[[Category: Sebald, W.]]
[[Category: Sebald, W.]]
-
[[Category: cytokine receptor,interleukin-4]]
+
[[Category: Cytokine receptor,interleukin-4]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:46:54 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:17:04 2008''
+

Revision as of 16:46, 2 May 2008

Image:1iar.jpg

Template:STRUCTURE 1iar

INTERLEUKIN-4 / RECEPTOR ALPHA CHAIN COMPLEX


Overview

Interleukin-4 (IL-4) is a principal regulatory cytokine during an immune response and a crucial determinant for allergy and asthma. IL-4 binds with high affinity and specificity to the ectodomain of the IL-4 receptor alpha chain (IL4-BP). Subsequently, this intermediate complex recruits the common gamma chain (gamma c), thereby initiating transmembrane signaling. The crystal structure of the intermediate complex between human IL-4 and IL4-BP was determined at 2.3 A resolution. It reveals a novel spatial orientation of the two proteins, a small but unexpected conformational change in the receptor-bound IL-4, and an interface with three separate clusters of trans-interacting residues. Novel insights on ligand binding in the cytokine receptor family and a paradigm for receptors of IL-2, IL-7, IL-9, and IL-15, which all utilize gamma c, are provided.

About this Structure

1IAR is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface., Hage T, Sebald W, Reinemer P, Cell. 1999 Apr 16;97(2):271-81. PMID:10219247 Page seeded by OCA on Fri May 2 19:46:54 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1iar"
Personal tools