7vv0

==Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with PAMP-12, local==

<StructureSection load='7vv0' size='340' side='right'caption='[[7vv0]], [[Resolution|resolution]] 3.50&Aring;' scene=''>

<table><tr><td colspan='2'>[[7vv0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VV0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VV0 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vv0 OCA], [https://pdbe.org/7vv0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vv0 RCSB], [https://www.ebi.ac.uk/pdbsum/7vv0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vv0 ProSAT]</span></td></tr>

== Function ==

[[https://www.uniprot.org/uniprot/ADML_HUMAN ADML_HUMAN]] AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.

[[Category: Homo sapiens]]

[[Category: Li Y]]

[[Category: Yang F]]