7zyi

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
====
+
==Structure of the human sodium/bile acid cotransporter (NTCP) in complex with Fab and nanobody==
-
<StructureSection load='7zyi' size='340' side='right'caption='[[7zyi]]' scene=''>
+
<StructureSection load='7zyi' size='340' side='right'caption='[[7zyi]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[7zyi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZYI FirstGlance]. <br>
-
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zyi OCA], [https://pdbe.org/7zyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zyi RCSB], [https://www.ebi.ac.uk/pdbsum/7zyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zyi ProSAT]</span></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CHO:GLYCOCHENODEOXYCHOLIC+ACID'>CHO</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zyi OCA], [https://pdbe.org/7zyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zyi RCSB], [https://www.ebi.ac.uk/pdbsum/7zyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zyi ProSAT]</span></td></tr>
</table>
</table>
 +
== Disease ==
 +
[[https://www.uniprot.org/uniprot/NTCP_HUMAN NTCP_HUMAN]] The disease is caused by variants affecting the gene represented in this entry.
 +
== Function ==
 +
[[https://www.uniprot.org/uniprot/NTCP_HUMAN NTCP_HUMAN]] As a major transporter of conjugated bile salts from plasma into the hepatocyte, it has a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins. It exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. Able to transport taurocholate, cholate, and the non-bile acid estron sulfate (PubMed:14660639, PubMed:24867799).<ref>PMID:14660639</ref> <ref>PMID:24867799</ref> (Microbial infection) Acts as a receptor for hepatitis B virus.<ref>PMID:23150796</ref>
 +
== References ==
 +
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Z-disk]]
+
[[Category: Mus musculus]]
 +
[[Category: Agrawal P]]
 +
[[Category: Bang-Sorensen R]]
 +
[[Category: Irobalieva RN]]
 +
[[Category: Kossiakoff AA]]
 +
[[Category: Liu H]]
 +
[[Category: Locher KP]]
 +
[[Category: Mukherjee S]]
 +
[[Category: Nosol K]]
 +
[[Category: Stieger B]]

Revision as of 05:35, 8 September 2022

Structure of the human sodium/bile acid cotransporter (NTCP) in complex with Fab and nanobody

PDB ID 7zyi

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/7zyi"
Personal tools