7ts2
From Proteopedia
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==Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 6-(3-(3,3-difluoroazetidin-1-yl)propyl)-4-methylpyridin-2-amine== | ==Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 6-(3-(3,3-difluoroazetidin-1-yl)propyl)-4-methylpyridin-2-amine== | ||
| - | <StructureSection load='7ts2' size='340' side='right'caption='[[7ts2]]' scene=''> | + | <StructureSection load='7ts2' size='340' side='right'caption='[[7ts2]], [[Resolution|resolution]] 1.98Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TS2 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7ts2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens_environmental_sample Homo sapiens environmental sample]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TS2 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ts2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ts2 OCA], [https://pdbe.org/7ts2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ts2 RCSB], [https://www.ebi.ac.uk/pdbsum/7ts2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ts2 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=K8F:6-[3-(3,3-difluoroazetidin-1-yl)propyl]-4-methylpyridin-2-amine'>K8F</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ts2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ts2 OCA], [https://pdbe.org/7ts2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ts2 RCSB], [https://www.ebi.ac.uk/pdbsum/7ts2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ts2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/NOS1_HUMAN NOS1_HUMAN]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens environmental sample]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Li H]] | [[Category: Li H]] | ||
[[Category: Poulos TL]] | [[Category: Poulos TL]] | ||
Revision as of 05:50, 8 September 2022
Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 6-(3-(3,3-difluoroazetidin-1-yl)propyl)-4-methylpyridin-2-amine
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