7wwg
From Proteopedia
(Difference between revisions)
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==Crystal structure of Saccharomyces cerevisiae Sfh2 complexed with phosphatidylinositol in an open conformation== | ==Crystal structure of Saccharomyces cerevisiae Sfh2 complexed with phosphatidylinositol in an open conformation== | ||
| - | <StructureSection load='7wwg' size='340' side='right'caption='[[7wwg]]' scene=''> | + | <StructureSection load='7wwg' size='340' side='right'caption='[[7wwg]], [[Resolution|resolution]] 3.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WWG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WWG FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7wwg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WWG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WWG FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wwg OCA], [https://pdbe.org/7wwg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wwg RCSB], [https://www.ebi.ac.uk/pdbsum/7wwg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wwg ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B7N:(1R)-2-{[(S)-HYDROXY{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXYL]OXY}PHOSPHORYL]OXY}-1-[(OCTADECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>B7N</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wwg OCA], [https://pdbe.org/7wwg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wwg RCSB], [https://www.ebi.ac.uk/pdbsum/7wwg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wwg ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/CSR1_YEAST CSR1_YEAST]] Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Activates SPO14/PLD1 (phospholipase D1) by stimulating phosphoinositide synthesis via the STT4 PtdIns 4-kinase. Modulates ArfGAP function through effects on SPO14 activity. Inhibits phosphatidylcholine degradation by PLB1 (phospholipase B1). May also regulate post-Golgi membrane-trafficking events and have a role resistance to oxidative stress. Inhibits fatty acid synthase activity in response to heme depletion and oleic acid starvation, preventing saturated fatty acid (SFA) accumulation (PubMed:17803462).<ref>PMID:10679005</ref> <ref>PMID:10848624</ref> <ref>PMID:12435498</ref> <ref>PMID:12824182</ref> <ref>PMID:12869188</ref> <ref>PMID:16126894</ref> <ref>PMID:16262726</ref> <ref>PMID:17803462</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Saccharomyces cerevisiae S288C]] | ||
[[Category: Chen L]] | [[Category: Chen L]] | ||
[[Category: Im YJ]] | [[Category: Im YJ]] | ||
[[Category: Tan L]] | [[Category: Tan L]] | ||
Revision as of 05:54, 8 September 2022
Crystal structure of Saccharomyces cerevisiae Sfh2 complexed with phosphatidylinositol in an open conformation
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