8d1i
From Proteopedia
(Difference between revisions)
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==hBest1 1uM Ca2+ (Ca2+-bound) closed state== | ==hBest1 1uM Ca2+ (Ca2+-bound) closed state== | ||
| - | <StructureSection load='8d1i' size='340' side='right'caption='[[8d1i]]' scene=''> | + | <StructureSection load='8d1i' size='340' side='right'caption='[[8d1i]], [[Resolution|resolution]] 1.82Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D1I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D1I FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[8d1i]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D1I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D1I FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d1i OCA], [https://pdbe.org/8d1i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d1i RCSB], [https://www.ebi.ac.uk/pdbsum/8d1i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d1i ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MC3:1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE'>MC3</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d1i OCA], [https://pdbe.org/8d1i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d1i RCSB], [https://www.ebi.ac.uk/pdbsum/8d1i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d1i ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/BEST1_HUMAN BEST1_HUMAN]] Nanophthalmos;Adult-onset foveomacular vitelliform dystrophy;Best vitelliform macular dystrophy;MRCS syndrome;Autosomal recessive bestrophinopathy;Autosomal dominant vitreoretinochoroidopathy;Retinitis pigmentosa. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/BEST1_HUMAN BEST1_HUMAN]] Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate.<ref>PMID:11904445</ref> <ref>PMID:12907679</ref> <ref>PMID:18400985</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Bestrophin 3D structures|Bestrophin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Hendrickson WA]] | [[Category: Hendrickson WA]] | ||
Revision as of 05:59, 8 September 2022
hBest1 1uM Ca2+ (Ca2+-bound) closed state
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