7fci

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Current revision (06:21, 8 September 2022) (edit) (undo)
 
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====
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==human NTCP in complex with YN69083 Fab==
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<StructureSection load='7fci' size='340' side='right'caption='[[7fci]]' scene=''>
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<StructureSection load='7fci' size='340' side='right'caption='[[7fci]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7fci]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FCI FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fci OCA], [https://pdbe.org/7fci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fci RCSB], [https://www.ebi.ac.uk/pdbsum/7fci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fci ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fci OCA], [https://pdbe.org/7fci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fci RCSB], [https://www.ebi.ac.uk/pdbsum/7fci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fci ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[[https://www.uniprot.org/uniprot/NTCP_HUMAN NTCP_HUMAN]] The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[[https://www.uniprot.org/uniprot/NTCP_HUMAN NTCP_HUMAN]] As a major transporter of conjugated bile salts from plasma into the hepatocyte, it has a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins. It exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. Able to transport taurocholate, cholate, and the non-bile acid estron sulfate (PubMed:14660639, PubMed:24867799).<ref>PMID:14660639</ref> <ref>PMID:24867799</ref> (Microbial infection) Acts as a receptor for hepatitis B virus.<ref>PMID:23150796</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: Mus musculus]]
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[[Category: Ishimoto N]]
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[[Category: Iwamoto M]]
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[[Category: Iwata S]]
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[[Category: Jin Z]]
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[[Category: Lee W]]
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[[Category: Liu K]]
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[[Category: Mizutani K]]
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[[Category: Muramatsu M]]
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[[Category: Nishizawa T]]
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[[Category: Nomura N]]
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[[Category: Ohki M]]
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[[Category: Oshima M]]
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[[Category: Park JH]]
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[[Category: Park SY]]
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[[Category: Shirouzu M]]
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[[Category: Son D]]
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[[Category: Tame JRH]]
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[[Category: Uchikubo-Kamo T]]
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[[Category: Uemura T]]
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[[Category: Wakita T]]
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[[Category: Watashi K]]
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[[Category: Yoshida H]]
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[[Category: Yun JH]]

Current revision

human NTCP in complex with YN69083 Fab

PDB ID 7fci

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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