7wzs
From Proteopedia
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| - | ==== | + | ==Crystal structure of Chromobacterium violaceum effector CopC in complex with host calmodulin and caspase-7== |
| - | <StructureSection load='7wzs' size='340' side='right'caption='[[7wzs]]' scene=''> | + | <StructureSection load='7wzs' size='340' side='right'caption='[[7wzs]], [[Resolution|resolution]] 3.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7wzs]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Chromobacterium_violaceum_ATCC_12472 Chromobacterium violaceum ATCC 12472] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WZS FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wzs OCA], [https://pdbe.org/7wzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wzs RCSB], [https://www.ebi.ac.uk/pdbsum/7wzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wzs ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wzs OCA], [https://pdbe.org/7wzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wzs RCSB], [https://www.ebi.ac.uk/pdbsum/7wzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wzs ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/COPC_CHRVO COPC_CHRVO]] ADP-riboxanase effector that inhibits host cell pyroptosis (PubMed:34671164). Acts by mediating arginine ADP-riboxanation of host CASP4/CASP11, blocking CASP4/CASP11 autoprocessing (PubMed:34671164). This prevents CASP4 activation and ability to recognize and cleave GSDMD, thereby inhibiting LPS-induced pyroptosis (PubMed:34671164). ADP-riboxanation takes place in two steps: CopC first catalyzes ADP-ribosylation of target Arg, and then initiates a deamination to remove one N-omega group (By similarity).[UniProtKB:A0A0H2US87]<ref>PMID:34671164</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Chromobacterium violaceum ATCC 12472]] | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Ding J]] |
Revision as of 06:28, 8 September 2022
Crystal structure of Chromobacterium violaceum effector CopC in complex with host calmodulin and caspase-7
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