7az0
From Proteopedia
(Difference between revisions)
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==Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with TH12161== | ==Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with TH12161== | ||
| - | <StructureSection load='7az0' size='340' side='right'caption='[[7az0]]' scene=''> | + | <StructureSection load='7az0' size='340' side='right'caption='[[7az0]], [[Resolution|resolution]] 2.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AZ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AZ0 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7az0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AZ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AZ0 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7az0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7az0 OCA], [https://pdbe.org/7az0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7az0 RCSB], [https://www.ebi.ac.uk/pdbsum/7az0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7az0 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SDW:2-cyclopropyl-~{N}-(4-iodophenyl)quinazolin-4-amine'>SDW</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7az0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7az0 OCA], [https://pdbe.org/7az0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7az0 RCSB], [https://www.ebi.ac.uk/pdbsum/7az0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7az0 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/OGG1_MOUSE OGG1_MOUSE]] DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
[[Category: Davies JR]] | [[Category: Davies JR]] | ||
[[Category: Masuyer G]] | [[Category: Masuyer G]] | ||
[[Category: Stenmark P]] | [[Category: Stenmark P]] | ||
Revision as of 07:12, 8 September 2022
Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with TH12161
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