7doq

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<StructureSection load='7doq' size='340' side='right'caption='[[7doq]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='7doq' size='340' side='right'caption='[[7doq]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7doq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DOQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DOQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7doq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DOQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DOQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7doq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7doq OCA], [https://pdbe.org/7doq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7doq RCSB], [https://www.ebi.ac.uk/pdbsum/7doq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7doq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7doq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7doq OCA], [https://pdbe.org/7doq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7doq RCSB], [https://www.ebi.ac.uk/pdbsum/7doq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7doq ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[[https://www.uniprot.org/uniprot/A0A2S6F805_LEGPN A0A2S6F805_LEGPN]]
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MapA is a histidine acid phosphatase (HAP) from Legionella pneumophila that catalyzes the hydroxylation of a phosphoryl group from phosphomonoesters by an active-site histidine. Several structures of HAPs, including MapA, in complex with the inhibitor tartrate have been solved and the substrate binding tunnel identified; however, the substrate recognition mechanism remains unknown. To gain insight into the mechanism of substrate recognition, the crystal structures of apo-MapA and the MapA(D281A) mutant in complex with 5'-AMP were solved at 2.2 and 2.6 A resolution, respectively. The structure of the MapA(D281A)/5'-AMP complex reveals that the 5'-AMP fits fully into the substrate binding tunnel, with the 2'-hydroxyl group of the ribose moiety stabilized by Glu201 and the adenine moiety sandwiched between His205 and Phe237. This is the second structure of a HAP/AMP complex solved with 5'-AMP binding in a unique manner in the active site. The structure presents a new substrate recognition mechanism of HAPs.
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Structural insights into a new substrate binding mode of a histidine acid phosphatase from Legionella pneumophila.,Guo Y, Zhou D, Zhang H, Zhang NN, Qi X, Chen X, Chen Q, Li J, Ge H, Teng YB Biochem Biophys Res Commun. 2021 Feb 12;540:90-94. doi:, 10.1016/j.bbrc.2020.12.070. Epub 2021 Jan 12. PMID:33450485<ref>PMID:33450485</ref>
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==See Also==
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*[[Acid phosphatase 3D structures|Acid phosphatase 3D structures]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7doq" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Guo, Y]]
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[[Category: Legionella pneumophila]]
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[[Category: Teng, Y]]
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[[Category: Guo Y]]
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[[Category: 5'-amp]]
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[[Category: Teng Y]]
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[[Category: Complex]]
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[[Category: Hydrolase]]
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Revision as of 07:12, 8 September 2022

Lp major histidine acid phosphatase mutant D281A/5'-AMP

PDB ID 7doq

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