7pqq
From Proteopedia
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| - | ==== | + | ==Structure of thermostabilised human NTCP in complex with Megabody 91== |
| - | <StructureSection load='7pqq' size='340' side='right'caption='[[7pqq]]' scene=''> | + | <StructureSection load='7pqq' size='340' side='right'caption='[[7pqq]], [[Resolution|resolution]] 3.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7pqq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PQQ FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pqq OCA], [https://pdbe.org/7pqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pqq RCSB], [https://www.ebi.ac.uk/pdbsum/7pqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pqq ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pqq OCA], [https://pdbe.org/7pqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pqq RCSB], [https://www.ebi.ac.uk/pdbsum/7pqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pqq ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/NTCP_HUMAN NTCP_HUMAN]] The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/NTCP_HUMAN NTCP_HUMAN]] As a major transporter of conjugated bile salts from plasma into the hepatocyte, it has a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins. It exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. Able to transport taurocholate, cholate, and the non-bile acid estron sulfate (PubMed:14660639, PubMed:24867799).<ref>PMID:14660639</ref> <ref>PMID:24867799</ref> (Microbial infection) Acts as a receptor for hepatitis B virus.<ref>PMID:23150796</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Lama glama]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Goutam K]] |
| + | [[Category: Reyes N]] | ||
Revision as of 07:18, 8 September 2022
Structure of thermostabilised human NTCP in complex with Megabody 91
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