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7q52

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<StructureSection load='7q52' size='340' side='right'caption='[[7q52]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
<StructureSection load='7q52' size='340' side='right'caption='[[7q52]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7q52]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q52 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q52 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7q52]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q52 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q52 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8ZC:2-azanyl-3-(4-fluorophenyl)carbonyl-indolizine-1-carboxamide'>8ZC</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8ZC:2-azanyl-3-(4-fluorophenyl)carbonyl-indolizine-1-carboxamide'>8ZC</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q52 OCA], [https://pdbe.org/7q52 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q52 RCSB], [https://www.ebi.ac.uk/pdbsum/7q52 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q52 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q52 OCA], [https://pdbe.org/7q52 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q52 RCSB], [https://www.ebi.ac.uk/pdbsum/7q52 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q52 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PKNG_MYCTU PKNG_MYCTU]] Phosphorylates GarA. May play a role in metabolic regulation via control of the phosphorylation status of GarA. Plays a crucial role in the survival of mycobacteria within host macrophages, by blocking the intracellular degradation of mycobacteria in lysosomes. Required for intrinsic antibiotic resistance.<ref>PMID:19019160</ref> <ref>PMID:19528288</ref> <ref>PMID:19638631</ref> <ref>PMID:17616581</ref>
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[[https://www.uniprot.org/uniprot/PKNG_MYCTU PKNG_MYCTU]] Phosphorylates GarA. May play a role in metabolic regulation via control of the phosphorylation status of GarA. Plays a crucial role in the survival of mycobacteria within host macrophages, by blocking the intracellular degradation of mycobacteria in lysosomes. Required for intrinsic antibiotic resistance.<ref>PMID:19019160</ref> <ref>PMID:19528288</ref> <ref>PMID:19638631</ref> <ref>PMID:17616581</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Bento, I]]
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[[Category: Bento I]]
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[[Category: Burastero, O]]
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[[Category: Burastero O]]
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[[Category: Defelipe, L A]]
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[[Category: Defelipe LA]]
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[[Category: Garcia-Alai, M M]]
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[[Category: Garcia-Alai MM]]
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[[Category: Inhibitor]]
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[[Category: L2w]]
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[[Category: Transferase]]
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[[Category: Tuberculosis]]
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Revision as of 07:18, 8 September 2022

Crystal structure of S/T protein kinase PknG from Mycobacterium tuberculosis in complex with inhibitor L2W

PDB ID 7q52

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