1ibr

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[[Image:1ibr.gif|left|200px]]
[[Image:1ibr.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ibr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ibr OCA], [http://www.ebi.ac.uk/pdbsum/1ibr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ibr RCSB]</span>
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'''COMPLEX OF RAN WITH IMPORTIN BETA'''
'''COMPLEX OF RAN WITH IMPORTIN BETA'''
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[[Category: Vetter, I R.]]
[[Category: Vetter, I R.]]
[[Category: Wittinghofer, A.]]
[[Category: Wittinghofer, A.]]
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[[Category: nuclear transport receptor]]
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[[Category: Nuclear transport receptor]]
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[[Category: small gtpase]]
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[[Category: Small gtpase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:49:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:17:30 2008''
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Revision as of 16:49, 2 May 2008

Image:1ibr.gif

Template:STRUCTURE 1ibr

COMPLEX OF RAN WITH IMPORTIN BETA


Overview

Transport receptors of the Importin beta family shuttle between the nucleus and cytoplasm and mediate transport of macromolecules through nuclear pore complexes. They interact specifically with the GTP-binding protein Ran, which in turn regulates their interaction with cargo. Here, we report the three-dimensional structure of a complex between Ran bound to the nonhydrolyzable GTP analog GppNHp and a 462-residue fragment from Importin beta. The structure of Importin beta shows 10 tandem repeats resembling HEAT and Armadillo motifs. They form an irregular crescent, the concave site of which forms the interface with Ran-triphosphate. The importin-binding site of Ran does not overlap with that of the Ran-binding domain of RanBP2.

About this Structure

1IBR is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural view of the Ran-Importin beta interaction at 2.3 A resolution., Vetter IR, Arndt A, Kutay U, Gorlich D, Wittinghofer A, Cell. 1999 May 28;97(5):635-46. PMID:10367892 Page seeded by OCA on Fri May 2 19:49:07 2008

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