7vu8

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Current revision (07:24, 8 September 2022) (edit) (undo)
 
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<StructureSection load='7vu8' size='340' side='right'caption='[[7vu8]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='7vu8' size='340' side='right'caption='[[7vu8]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7vu8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VU8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VU8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7vu8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Linum_usitatissimum Linum usitatissimum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VU8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VU8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACK:(3AR,4R,6R,6AR)-4-(6-AMINO-9H-PURIN-9-YL)-6-(HYDROXYMETHYL)TETRAHYDROFURO[3,4-D][1,3,2]DIOXAPHOSPHOL-2-OL+2-OXIDE'>ACK</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACK:(3AR,4R,6R,6AR)-4-(6-AMINO-9H-PURIN-9-YL)-6-(HYDROXYMETHYL)TETRAHYDROFURO[3,4-D][1,3,2]DIOXAPHOSPHOL-2-OL+2-OXIDE'>ACK</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vu8 OCA], [https://pdbe.org/7vu8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vu8 RCSB], [https://www.ebi.ac.uk/pdbsum/7vu8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vu8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vu8 OCA], [https://pdbe.org/7vu8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vu8 RCSB], [https://www.ebi.ac.uk/pdbsum/7vu8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vu8 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[[https://www.uniprot.org/uniprot/Q9XEH4_LINUS Q9XEH4_LINUS]]
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2',3'-cAMP is a positional isomer of the well-established second messenger 3',5'-cAMP, but little is known about the biology of this noncanonical cyclic nucleotide monophosphate (cNMP). Toll/interleukin-1 receptor (TIR) domains of nucleotide-binding leucine-rich repeat (NLR) immune receptors have the NADase function necessary but insufficient to activate plant immune responses. Here, we show that plant TIR proteins, besides being NADases, act as 2',3'-cAMP/cGMP synthetases by hydrolyzing RNA/DNA. Structural data show that a TIR domain adopts distinct oligomers with mutually exclusive NADase and synthetase activity. Mutations specifically disrupting the synthetase activity abrogate TIR-mediated cell death in Nicotiana benthamiana (Nb), supporting an important role for these cNMPs in TIR signaling. Furthermore, the Arabidopsis negative regulator of TIR-NLR signaling, NUDT7, displays 2',3'-cAMP/cGMP but not 3',5'-cAMP/cGMP phosphodiesterase activity and suppresses cell death activity of TIRs in Nb. Our study identifies a family of 2',3'-cAMP/cGMP synthetases and establishes a critical role for them in plant immune responses.
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TIR domains of plant immune receptors are 2',3'-cAMP/cGMP synthetases mediating cell death.,Yu D, Song W, Tan EYJ, Liu L, Cao Y, Jirschitzka J, Li E, Logemann E, Xu C, Huang S, Jia A, Chang X, Han Z, Wu B, Schulze-Lefert P, Chai J Cell. 2022 May 13. pii: S0092-8674(22)00530-X. doi: 10.1016/j.cell.2022.04.032. PMID:35597242<ref>PMID:35597242</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7vu8" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chai, J]]
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[[Category: Linum usitatissimum]]
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[[Category: Schulze-Lefert, P]]
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[[Category: Chai J]]
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[[Category: Song, W]]
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[[Category: Schulze-Lefert P]]
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[[Category: Tan, Y]]
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[[Category: Song W]]
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[[Category: Wu, B]]
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[[Category: Tan Y]]
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[[Category: Xu, C]]
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[[Category: Wu B]]
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[[Category: Yu, D]]
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[[Category: Xu C]]
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[[Category: Hydrolase]]
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[[Category: Yu D]]
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[[Category: Nucleic acid hydrolysis complex]]
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Current revision

L7-Tir domain with bound ligand

PDB ID 7vu8

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