Gluconeogenesis
From Proteopedia
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<StructureSection load='2y3i' size='350' side='right' scene='' caption='Human phosphoglycerate kinase complex with phosphoglyceric acid, ADP (stick model) AlF4-, Cl- and Mg+2 ions (green) (PDB code [[2y3i]])'> | <StructureSection load='2y3i' size='350' side='right' scene='' caption='Human phosphoglycerate kinase complex with phosphoglyceric acid, ADP (stick model) AlF4-, Cl- and Mg+2 ions (green) (PDB code [[2y3i]])'> | ||
| - | Gluconeogenesis is a metabolic pathway that results in the generation of glucose from certain non-carbohydrate carbon substrates. Phosphoglycerate kinase | + | Gluconeogenesis is a metabolic pathway that results in the generation of glucose from certain non-carbohydrate carbon substrates. [[Phosphoglycerate Kinase|Phosphoglycerate kinase]] is an enzyme that catalyzes the reversible transfer of a phosphate group from 1,3-bisphosphoglycerate (1,3-BPG) to ADP producing 3-phosphoglycerate (3-PG) and ATP : |
1,3-bisphosphoglycerate + ADP ⇌ glycerate 3-phosphate + ATP | 1,3-bisphosphoglycerate + ADP ⇌ glycerate 3-phosphate + ATP | ||
| - | Like all kinases it is a transferase. PGK is a major enzyme used in glycolysis, in the first ATP-generating step of the glycolytic pathway. In gluconeogenesis, the reaction catalyzed by PGK proceeds in the opposite direction, generating ADP and 1,3-BPG. | + | Like all kinases it is a transferase. PGK is a major enzyme used in glycolysis, in the first ATP-generating step of the glycolytic pathway. In '''gluconeogenesis''', the reaction catalyzed by PGK proceeds in the opposite direction, generating ADP and 1,3-BPG. |
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 11:24, 12 September 2022
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