1iby

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[[Image:1iby.jpg|left|200px]]
[[Image:1iby.jpg|left|200px]]
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{{Structure
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|PDB= 1iby |SIZE=350|CAPTION= <scene name='initialview01'>1iby</scene>, resolution 1.65&Aring;
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The line below this paragraph, containing "STRUCTURE_1iby", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene>
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{{STRUCTURE_1iby| PDB=1iby | SCENE= }}
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|RELATEDENTRY=[[1ibz|1IBZ]], [[1ic0|1IC0]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iby OCA], [http://www.ebi.ac.uk/pdbsum/1iby PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1iby RCSB]</span>
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}}
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'''RED COPPER PROTEIN NITROSOCYANIN FROM NITROSOMONAS EUROPAEA'''
'''RED COPPER PROTEIN NITROSOCYANIN FROM NITROSOMONAS EUROPAEA'''
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[[Category: Lieberman, R L.]]
[[Category: Lieberman, R L.]]
[[Category: Rosenzweig, A C.]]
[[Category: Rosenzweig, A C.]]
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[[Category: beta hairpin]]
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[[Category: Beta hairpin]]
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[[Category: cupredoxin]]
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[[Category: Cupredoxin]]
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[[Category: nitrosocyanin]]
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[[Category: Nitrosocyanin]]
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[[Category: nitrosomonas europaea]]
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[[Category: Nitrosomonas europaea]]
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[[Category: red copper]]
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[[Category: Red copper]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:49:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:17:35 2008''
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Revision as of 16:49, 2 May 2008

Image:1iby.jpg

Template:STRUCTURE 1iby

RED COPPER PROTEIN NITROSOCYANIN FROM NITROSOMONAS EUROPAEA


Overview

Nitrosocyanin (NC) is a mononuclear red copper protein isolated from the ammonia oxidizing bacterium Nitrosomonas europaea. Although NC exhibits some sequence homology to classic blue copper proteins, its spectroscopic and electrochemical properties are drastically different. The 1.65 A resolution crystal structure of oxidized NC reveals an unprecedented trimer of single domain cupredoxins. Each copper center is partially covered by an unusual extended beta-hairpin structure from an adjacent monomer. The copper ion is coordinated by His 98, His 103, Cys 95, a single side chain oxygen of Glu 60, and a solvent molecule. In the 2.3 A resolution structure of reduced NC, His 98 shifts away from the copper ion, and the solvent molecule is not observed. The arrangement of these ligands renders the coordination geometry of the NC red copper center distinct from that of blue copper centers. In particular, the red copper center has a higher coordination number and lacks the long Cu-S(Met) and short Cu-S(Cys) bond distances characteristic of blue copper. Moreover, the red copper center is square pyramidal whereas blue copper is typically distorted tetrahedral. Analysis of the NC structure provides insight into possible functions of this new type of biological copper center.

About this Structure

1IBY is a Single protein structure of sequence from Nitrosomonas europaea. Full crystallographic information is available from OCA.

Reference

Crystal structure of a novel red copper protein from Nitrosomonas europaea., Lieberman RL, Arciero DM, Hooper AB, Rosenzweig AC, Biochemistry. 2001 May 15;40(19):5674-81. PMID:11341832 Page seeded by OCA on Fri May 2 19:49:34 2008

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