1ic8

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[[Image:1ic8.gif|left|200px]]
[[Image:1ic8.gif|left|200px]]
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{{Structure
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|PDB= 1ic8 |SIZE=350|CAPTION= <scene name='initialview01'>1ic8</scene>, resolution 2.6&Aring;
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The line below this paragraph, containing "STRUCTURE_1ic8", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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{{STRUCTURE_1ic8| PDB=1ic8 | SCENE= }}
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|RELATEDENTRY=[[1au7|1AU7]], [[1oct|1OCT]], [[1lfb|1LFB]], [[2lfb|2LFB]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ic8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ic8 OCA], [http://www.ebi.ac.uk/pdbsum/1ic8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ic8 RCSB]</span>
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}}
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'''HEPATOCYTE NUCLEAR FACTOR 1A BOUND TO DNA : MODY3 GENE PRODUCT'''
'''HEPATOCYTE NUCLEAR FACTOR 1A BOUND TO DNA : MODY3 GENE PRODUCT'''
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[[Category: Oh, B-.C.]]
[[Category: Oh, B-.C.]]
[[Category: Shoelson, S E.]]
[[Category: Shoelson, S E.]]
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[[Category: diabetes]]
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[[Category: Diabetes]]
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[[Category: disease mutation]]
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[[Category: Disease mutation]]
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[[Category: dna-binding]]
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[[Category: Dna-binding]]
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[[Category: mody3]]
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[[Category: Mody3]]
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[[Category: pou domain]]
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[[Category: Pou domain]]
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[[Category: transcription regulation]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:50:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:17:45 2008''
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Revision as of 16:50, 2 May 2008

Image:1ic8.gif

Template:STRUCTURE 1ic8

HEPATOCYTE NUCLEAR FACTOR 1A BOUND TO DNA : MODY3 GENE PRODUCT


Overview

Mutations in Hnf-1alpha are the most common Mendelian cause of diabetes mellitus. To elucidate the molecular function of a mutational hotspot, we cocrystallized human HNF-1alpha 83-279 with a high-affinity promoter and solved the structure of the complex. Two identical protein molecules are bound to the promoter. Each contains a homeodomain and a second domain structurally similar to POU-specific domains that was not predicted on the basis of amino acid sequence. Atypical elements in both domains create a stable interface that further distinguishes HNF-1alpha from other flexible POU-homeodomain proteins. The numerous diabetes-causing mutations in HNF-1alpha thus identified a previously unrecognized POU domain which was used as a search model to identify additional POU domain proteins in sequence databases.

About this Structure

1IC8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Diabetes mutations delineate an atypical POU domain in HNF-1alpha., Chi YI, Frantz JD, Oh BC, Hansen L, Dhe-Paganon S, Shoelson SE, Mol Cell. 2002 Nov;10(5):1129-37. PMID:12453420 Page seeded by OCA on Fri May 2 19:50:15 2008

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