1ic9

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[[Image:1ic9.gif|left|200px]]
[[Image:1ic9.gif|left|200px]]
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{{Structure
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|PDB= 1ic9 |SIZE=350|CAPTION= <scene name='initialview01'>1ic9</scene>
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The line below this paragraph, containing "STRUCTURE_1ic9", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DPR:D-PROLINE'>DPR</scene>
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{{STRUCTURE_1ic9| PDB=1ic9 | SCENE= }}
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|RELATEDENTRY=[[1icl|1ICL]], [[1ico|1ICO]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ic9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ic9 OCA], [http://www.ebi.ac.uk/pdbsum/1ic9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ic9 RCSB]</span>
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'''NMR SOLUTION STRUCTURE OF THE DESIGNED BETA-SHEET MINI-PROTEIN TH10AOX'''
'''NMR SOLUTION STRUCTURE OF THE DESIGNED BETA-SHEET MINI-PROTEIN TH10AOX'''
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==About this Structure==
==About this Structure==
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1IC9 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IC9 OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IC9 OCA].
==Reference==
==Reference==
Design of a discretely folded mini-protein motif with predominantly beta-structure., Ottesen JJ, Imperiali B, Nat Struct Biol. 2001 Jun;8(6):535-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11373623 11373623]
Design of a discretely folded mini-protein motif with predominantly beta-structure., Ottesen JJ, Imperiali B, Nat Struct Biol. 2001 Jun;8(6):535-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11373623 11373623]
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[[Category: Protein complex]]
 
[[Category: Imperiali, B.]]
[[Category: Imperiali, B.]]
[[Category: Ottesen, J J.]]
[[Category: Ottesen, J J.]]
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[[Category: three stranded antiparallel beta-sheet mini-protein motif de novo protein design]]
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[[Category: Three stranded antiparallel beta-sheet mini-protein motif de novo protein design]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:50:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:17:41 2008''
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Revision as of 16:50, 2 May 2008

Image:1ic9.gif

Template:STRUCTURE 1ic9

NMR SOLUTION STRUCTURE OF THE DESIGNED BETA-SHEET MINI-PROTEIN TH10AOX


Overview

Here we report the creation of a predominantly beta-structured mini-protein motif. The design target is based on the naturally occurring toxin hand (TH) motifs that are composed of four disulfide bonds and three loops that form a 'hand'. Analysis and subsequent modification of several generations of mini-proteins produced the final 29-residue mini-protein. The structured motif of this new mini-protein provides insight into the compensatory changes that result in the formation of a tightly packed hydrophobic core in a small, globular beta-structure motif. Additionally, this mini-motif represents a new, distinct surface topology for protein design and a valuable, yet compact, model system for the study of beta-sheet structure in water.

About this Structure

Full crystallographic information is available from OCA.

Reference

Design of a discretely folded mini-protein motif with predominantly beta-structure., Ottesen JJ, Imperiali B, Nat Struct Biol. 2001 Jun;8(6):535-9. PMID:11373623 Page seeded by OCA on Fri May 2 19:50:17 2008

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