1ice

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[[Image:1ice.jpg|left|200px]]
[[Image:1ice.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1ice |SIZE=350|CAPTION= <scene name='initialview01'>1ice</scene>, resolution 2.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1ice", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-1 Caspase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.36 3.4.22.36] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1ice| PDB=1ice | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ice FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ice OCA], [http://www.ebi.ac.uk/pdbsum/1ice PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ice RCSB]</span>
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}}
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'''STRUCTURE AND MECHANISM OF INTERLEUKIN-1BETA CONVERTING ENZYME'''
'''STRUCTURE AND MECHANISM OF INTERLEUKIN-1BETA CONVERTING ENZYME'''
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==About this Structure==
==About this Structure==
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1ICE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. The following page contains interesting information on the relation of 1ICE with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb56_1.html Caspases]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ICE OCA].
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1ICE is a [[Single protein]] structure. The following page contains interesting information on the relation of 1ICE with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb56_1.html Caspases]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ICE OCA].
==Reference==
==Reference==
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[[Category: Navia, M A.]]
[[Category: Navia, M A.]]
[[Category: Wilson, K P.]]
[[Category: Wilson, K P.]]
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[[Category: cytokine]]
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[[Category: Cytokine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:50:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:17:46 2008''
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Revision as of 16:50, 2 May 2008

Image:1ice.jpg

Template:STRUCTURE 1ice

STRUCTURE AND MECHANISM OF INTERLEUKIN-1BETA CONVERTING ENZYME


Overview

Interleukin-1 beta converting enzyme (ICE) processes an inactive precursor to the proinflammatory cytokine, interleukin-1 beta, and may regulate programmed cell death in neuronal cells. The high-resolution structure of human ICE in complex with an inhibitor has been determined by X-ray diffraction. The structure confirms the relationship between human ICE and cell-death proteins in other organisms. The active site spans both the 10 and 20K subunits, which associate to form a tetramer, suggesting a mechanism for ICE autoactivation.

About this Structure

1ICE is a Single protein structure. The following page contains interesting information on the relation of 1ICE with [Caspases]. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of interleukin-1 beta converting enzyme., Wilson KP, Black JA, Thomson JA, Kim EE, Griffith JP, Navia MA, Murcko MA, Chambers SP, Aldape RA, Raybuck SA, et al., Nature. 1994 Jul 28;370(6487):270-5. PMID:8035875 Page seeded by OCA on Fri May 2 19:50:26 2008

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