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1icg

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[[Image:1icg.gif|left|200px]]
[[Image:1icg.gif|left|200px]]
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{{Structure
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|PDB= 1icg |SIZE=350|CAPTION= <scene name='initialview01'>1icg</scene>, resolution 1.53&Aring;
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The line below this paragraph, containing "STRUCTURE_1icg", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=IRI:IRIDIUM+HEXAMMINE+ION'>IRI</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>, <scene name='pdbligand=UFP:5-FLUORO-2&#39;-DEOXYURIDINE-5&#39;-MONOPHOSPHATE'>UFP</scene>
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{{STRUCTURE_1icg| PDB=1icg | SCENE= }}
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|RELATEDENTRY=[[165d|165D]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1icg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1icg OCA], [http://www.ebi.ac.uk/pdbsum/1icg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1icg RCSB]</span>
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'''STRUCTURE OF THE HYBRID RNA/DNA R-GCUUCGGC-D[F]U IN PRESENCE OF IR(NH3)6+++'''
'''STRUCTURE OF THE HYBRID RNA/DNA R-GCUUCGGC-D[F]U IN PRESENCE OF IR(NH3)6+++'''
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==About this Structure==
==About this Structure==
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1ICG is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ICG OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ICG OCA].
==Reference==
==Reference==
Destabilizing effect of a fluorouracil extra base in a hybrid RNA duplex compared with bromo and chloro analogues., Cruse W, Saludjian P, Neuman A, Prange T, Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt 11):1609-13. Epub 2001, Oct 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11679725 11679725]
Destabilizing effect of a fluorouracil extra base in a hybrid RNA duplex compared with bromo and chloro analogues., Cruse W, Saludjian P, Neuman A, Prange T, Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt 11):1609-13. Epub 2001, Oct 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11679725 11679725]
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[[Category: Protein complex]]
 
[[Category: Cruse, W.]]
[[Category: Cruse, W.]]
[[Category: Neuman, A.]]
[[Category: Neuman, A.]]
[[Category: Prange, T.]]
[[Category: Prange, T.]]
[[Category: Saludjian, P.]]
[[Category: Saludjian, P.]]
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[[Category: c-u mismatch]]
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[[Category: C-u mismatch]]
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[[Category: fluoro-uracil]]
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[[Category: Fluoro-uracil]]
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[[Category: g-u mismatch]]
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[[Category: G-u mismatch]]
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[[Category: iridium hexammine]]
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[[Category: Iridium hexammine]]
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[[Category: rhodium hexammine]]
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[[Category: Rhodium hexammine]]
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[[Category: rna/dna hybrid]]
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[[Category: Rna/dna hybrid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:50:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:17:46 2008''
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Revision as of 16:50, 2 May 2008

Image:1icg.gif

Template:STRUCTURE 1icg

STRUCTURE OF THE HYBRID RNA/DNA R-GCUUCGGC-D[F]U IN PRESENCE OF IR(NH3)6+++


Overview

In the presence of cobalt, rhodium or iridium hexammine salts, the RNA/DNA hybrid r-GCUUCGGC-d(X)U (with X = F, Cl or Br) crystallizes as a double-stranded helix with four consecutive G-U and C-U mismatches. The deoxy chloro- and bromouracil derivatives are isomorphous, space group C2, unit-cell parameters a = 53.80, b = 19.40, c = 50.31 A, beta = 109.9 degrees, with the same infinite helix arrangement in the packing along the c axis with one extra DNA halogenouracil base included in the stacking. However, the fluorouracil derivative, with unit-cell parameters a = 53.75, b = 19.40, c = 45.84 A, beta = 105.7 degrees, is not isomorphous. The corresponding extra DNA base d(F)U of the second strand is ejected out of the helical stack, leading to a shortening of the c axis. The specific destabilization of the fluorouracil for the duplex building is analyzed in terms of the polarization effect of the halogen atom attached to the 3'-terminal base that modulates its interactions.

About this Structure

Full crystallographic information is available from OCA.

Reference

Destabilizing effect of a fluorouracil extra base in a hybrid RNA duplex compared with bromo and chloro analogues., Cruse W, Saludjian P, Neuman A, Prange T, Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt 11):1609-13. Epub 2001, Oct 25. PMID:11679725 Page seeded by OCA on Fri May 2 19:50:29 2008

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