1ico

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[[Image:1ico.jpg|left|200px]]
[[Image:1ico.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1ico |SIZE=350|CAPTION= <scene name='initialview01'>1ico</scene>
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The line below this paragraph, containing "STRUCTURE_1ico", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DPR:D-PROLINE'>DPR</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|DOMAIN=
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{{STRUCTURE_1ico| PDB=1ico | SCENE= }}
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|RELATEDENTRY=[[1icl|1ICL]], [[1ic9|1IC9]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ico FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ico OCA], [http://www.ebi.ac.uk/pdbsum/1ico PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ico RCSB]</span>
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}}
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'''SOLUTION STRUCTURE OF DESIGNED BETA-SHEET MINI-PROTEIN TH10BOX'''
'''SOLUTION STRUCTURE OF DESIGNED BETA-SHEET MINI-PROTEIN TH10BOX'''
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==About this Structure==
==About this Structure==
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1ICO is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ICO OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ICO OCA].
==Reference==
==Reference==
Design of a discretely folded mini-protein motif with predominantly beta-structure., Ottesen JJ, Imperiali B, Nat Struct Biol. 2001 Jun;8(6):535-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11373623 11373623]
Design of a discretely folded mini-protein motif with predominantly beta-structure., Ottesen JJ, Imperiali B, Nat Struct Biol. 2001 Jun;8(6):535-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11373623 11373623]
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[[Category: Protein complex]]
 
[[Category: Imperiali, B.]]
[[Category: Imperiali, B.]]
[[Category: Ottesen, J J.]]
[[Category: Ottesen, J J.]]
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[[Category: de novo protein design three-stranded beta-sheet mini-protein motif th motif]]
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[[Category: De novo protein design three-stranded beta-sheet mini-protein motif th motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:50:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:17:55 2008''
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Revision as of 16:50, 2 May 2008

Image:1ico.jpg

Template:STRUCTURE 1ico

SOLUTION STRUCTURE OF DESIGNED BETA-SHEET MINI-PROTEIN TH10BOX


Overview

Here we report the creation of a predominantly beta-structured mini-protein motif. The design target is based on the naturally occurring toxin hand (TH) motifs that are composed of four disulfide bonds and three loops that form a 'hand'. Analysis and subsequent modification of several generations of mini-proteins produced the final 29-residue mini-protein. The structured motif of this new mini-protein provides insight into the compensatory changes that result in the formation of a tightly packed hydrophobic core in a small, globular beta-structure motif. Additionally, this mini-motif represents a new, distinct surface topology for protein design and a valuable, yet compact, model system for the study of beta-sheet structure in water.

About this Structure

Full crystallographic information is available from OCA.

Reference

Design of a discretely folded mini-protein motif with predominantly beta-structure., Ottesen JJ, Imperiali B, Nat Struct Biol. 2001 Jun;8(6):535-9. PMID:11373623 Page seeded by OCA on Fri May 2 19:50:58 2008

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