1id3
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1id3.gif|left|200px]] | [[Image:1id3.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1id3", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | + | {{STRUCTURE_1id3| PDB=1id3 | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''CRYSTAL STRUCTURE OF THE YEAST NUCLEOSOME CORE PARTICLE REVEALS FUNDAMENTAL DIFFERENCES IN INTER-NUCLEOSOME INTERACTIONS''' | '''CRYSTAL STRUCTURE OF THE YEAST NUCLEOSOME CORE PARTICLE REVEALS FUNDAMENTAL DIFFERENCES IN INTER-NUCLEOSOME INTERACTIONS''' | ||
| Line 29: | Line 26: | ||
[[Category: Suto, R K.]] | [[Category: Suto, R K.]] | ||
[[Category: White, C L.]] | [[Category: White, C L.]] | ||
| - | [[Category: | + | [[Category: Chromatin]] |
| - | [[Category: | + | [[Category: Histone]] |
| - | [[Category: | + | [[Category: Nucleoprotein]] |
| - | [[Category: | + | [[Category: Nucleosome core particle]] |
| - | + | [[Category: Protein/dna interaction]] | |
| - | [[Category: | + | [[Category: Supercoiled dna]] |
| - | [[Category: | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:51:48 2008'' |
| - | + | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 16:51, 2 May 2008
CRYSTAL STRUCTURE OF THE YEAST NUCLEOSOME CORE PARTICLE REVEALS FUNDAMENTAL DIFFERENCES IN INTER-NUCLEOSOME INTERACTIONS
Overview
Chromatin is composed of nucleosomes, the universally repeating protein-DNA complex in eukaryotic cells. The crystal structure of the nucleosome core particle from Saccharomyces cerevisiae reveals that the structure and function of this fundamental complex is conserved between single-cell organisms and metazoans. Our results show that yeast nucleosomes are likely to be subtly destabilized as compared with nucleosomes from higher eukaryotes, consistent with the idea that much of the yeast genome remains constitutively open during much of its life cycle. Importantly, minor sequence variations lead to dramatic changes in the way in which nucleosomes pack against each other within the crystal lattice. This has important implications for our understanding of the formation of higher order chromatin structure and its modulation by post-translational modifications. Finally, the yeast nucleosome core particle provides a structural context by which to interpret genetic data obtained from yeast. Coordinates have been deposited with the Protein Data Bank under accession number 1ID3.
About this Structure
1ID3 is a Protein complex structure of sequences from Homo sapiens and Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Structure of the yeast nucleosome core particle reveals fundamental changes in internucleosome interactions., White CL, Suto RK, Luger K, EMBO J. 2001 Sep 17;20(18):5207-18. PMID:11566884 Page seeded by OCA on Fri May 2 19:51:48 2008
