1idm

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[[Image:1idm.jpg|left|200px]]
[[Image:1idm.jpg|left|200px]]
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{{Structure
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|PDB= 1idm |SIZE=350|CAPTION= <scene name='initialview01'>1idm</scene>, resolution 2.2&Aring;
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The line below this paragraph, containing "STRUCTURE_1idm", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/3-isopropylmalate_dehydrogenase 3-isopropylmalate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.85 1.1.1.85] </span>
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{{STRUCTURE_1idm| PDB=1idm | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1idm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1idm OCA], [http://www.ebi.ac.uk/pdbsum/1idm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1idm RCSB]</span>
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'''3-ISOPROPYLMALATE DEHYDROGENASE, LOOP-DELETED CHIMERA'''
'''3-ISOPROPYLMALATE DEHYDROGENASE, LOOP-DELETED CHIMERA'''
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[[Category: Sato, M.]]
[[Category: Sato, M.]]
[[Category: Tanaka, N.]]
[[Category: Tanaka, N.]]
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[[Category: chimera]]
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[[Category: Chimera]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:52:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:18:19 2008''
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Revision as of 16:53, 2 May 2008

Image:1idm.jpg

Template:STRUCTURE 1idm

3-ISOPROPYLMALATE DEHYDROGENASE, LOOP-DELETED CHIMERA


Overview

A loop-deleted mutant form of 3-isopropylmalate dehydrogenase from Thermus thermophilus was constructed to investigate the relationship between the flexibility of the structure and the thermostability of the enzyme. The structure of the mutant enzyme was determined by X-ray crystallography and was found to be almost the same as that of the native enzyme with a reduced temperature factor. Although the mutant protein had lost the flexible loop, its function and thermostability had remained unchanged. This phenomenon can be explained by an internal reprieve tolerance mechanism.

About this Structure

1IDM is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Structure of a loop-deleted variant of 3-isopropylmalate dehydrogenase from Thermus thermophilus: an internal reprieve tolerance mechanism., Sakurai M, Ohzeki M, Miyazaki K, Moriyama H, Sato M, Tanaka N, Oshima T, Acta Crystallogr D Biol Crystallogr. 1996 Jan 1;52(Pt 1):124-8. PMID:15299733 Page seeded by OCA on Fri May 2 19:52:59 2008

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