4cv8
From Proteopedia
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<StructureSection load='4cv8' size='340' side='right'caption='[[4cv8]], [[Resolution|resolution]] 3.00Å' scene=''> | <StructureSection load='4cv8' size='340' side='right'caption='[[4cv8]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4cv8]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4cv8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CV8 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3D7:3-AMINO-5-(1-METHYL-1H-PYRAZOL-4-YL)PYRIDIN-2(1H)-ONE'>3D7</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3D7:3-AMINO-5-(1-METHYL-1H-PYRAZOL-4-YL)PYRIDIN-2(1H)-ONE'>3D7</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cv8 OCA], [https://pdbe.org/4cv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cv8 RCSB], [https://www.ebi.ac.uk/pdbsum/4cv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cv8 ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> |
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| + | ==See Also== | ||
| + | *[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Bavetsias | + | [[Category: Bavetsias V]] |
| - | [[Category: Bayliss | + | [[Category: Bayliss R]] |
| - | [[Category: Fearon | + | [[Category: Fearon D]] |
| - | [[Category: Jones | + | [[Category: Jones K]] |
| - | [[Category: Schmitt | + | [[Category: Schmitt J]] |
| - | [[Category: Westwood | + | [[Category: Westwood IM]] |
| - | [[Category: VanMontfort | + | [[Category: VanMontfort RLM]] |
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Revision as of 07:34, 14 September 2022
MPS1 kinase with 3-aminopyridin-2-one inhibitors
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