4d09

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<StructureSection load='4d09' size='340' side='right'caption='[[4d09]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='4d09' size='340' side='right'caption='[[4d09]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4d09]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D09 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D09 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4d09]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D09 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D09 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=788:N-BENZYL-4-METHYL-1-PHENYL[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE-8-CARBOXAMIDE'>788</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=788:N-BENZYL-4-METHYL-1-PHENYL[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE-8-CARBOXAMIDE'>788</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4d08|4d08]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d09 OCA], [https://pdbe.org/4d09 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d09 RCSB], [https://www.ebi.ac.uk/pdbsum/4d09 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d09 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d09 OCA], [http://pdbe.org/4d09 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d09 RCSB], [http://www.ebi.ac.uk/pdbsum/4d09 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d09 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PDE2A_HUMAN PDE2A_HUMAN]] Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.<ref>PMID:15938621</ref> <ref>PMID:19828435</ref>
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[[https://www.uniprot.org/uniprot/PDE2A_HUMAN PDE2A_HUMAN]] Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.<ref>PMID:15938621</ref> <ref>PMID:19828435</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Phosphodiesterase|Phosphodiesterase]]
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Andres, J I]]
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[[Category: Andres JI]]
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[[Category: Buijnsters, P]]
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[[Category: Buijnsters P]]
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[[Category: DeAngelis, M]]
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[[Category: DeAngelis M]]
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[[Category: Langlois, X]]
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[[Category: Langlois X]]
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[[Category: Rombouts, F]]
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[[Category: Rombouts F]]
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[[Category: Sanderson, W]]
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[[Category: Sanderson W]]
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[[Category: Trabanco, A]]
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[[Category: Trabanco A]]
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[[Category: Tresadern, G]]
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[[Category: Tresadern G]]
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[[Category: VanHoof, G]]
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[[Category: VanHoof G]]
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[[Category: VanRoosbroeck, Y]]
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[[Category: VanRoosbroeck Y]]
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[[Category: Animal]]
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[[Category: Cyclic nucleotide phosphodiesterase]]
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[[Category: Disease model]]
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[[Category: Drug evaluation]]
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[[Category: Hydrolase]]
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[[Category: Phosphodiesterase 2 inhibitor]]
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[[Category: Phosphodiesterase inhibitor]]
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[[Category: Preclinical]]
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[[Category: Protein binding]]
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[[Category: Structure-activity relationship]]
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[[Category: Type 2]]
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[[Category: Type 4]]
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Revision as of 07:40, 14 September 2022

PDE2a catalytic domain in complex with a brain penetrant inhibitor

PDB ID 4d09

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