4d2s

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<StructureSection load='4d2s' size='340' side='right'caption='[[4d2s]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='4d2s' size='340' side='right'caption='[[4d2s]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4d2s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D2S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D2S FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4d2s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D2S FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DYK:N-{2-METHOXY-4-[(1-METHYLPIPERIDIN-4-YL)OXY]PHENYL}-4-(1H-PYRROLO[2,3-C]PYRIDIN-3-YL)PYRIMIDIN-2-AMINE'>DYK</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DYK:N-{2-METHOXY-4-[(1-METHYLPIPERIDIN-4-YL)OXY]PHENYL}-4-(1H-PYRROLO[2,3-C]PYRIDIN-3-YL)PYRIMIDIN-2-AMINE'>DYK</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4d2r|4d2r]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d2s OCA], [https://pdbe.org/4d2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d2s RCSB], [https://www.ebi.ac.uk/pdbsum/4d2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d2s ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d2s OCA], [http://pdbe.org/4d2s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d2s RCSB], [http://www.ebi.ac.uk/pdbsum/4d2s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d2s ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
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[[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dual-specificity kinase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ballard, P]]
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[[Category: Ballard P]]
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[[Category: Bardelle, C]]
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[[Category: Bardelle C]]
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[[Category: Butterworth, S]]
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[[Category: Butterworth S]]
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[[Category: Colclough, N]]
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[[Category: Colclough N]]
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[[Category: Critchlow, S E]]
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[[Category: Critchlow SE]]
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[[Category: Debreczeni, J E]]
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[[Category: Debreczeni JE]]
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[[Category: Fairley, G]]
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[[Category: Fairley G]]
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[[Category: Fillery, S]]
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[[Category: Fillery S]]
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[[Category: Goodwin, L]]
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[[Category: Goodwin L]]
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[[Category: Graham, M A]]
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[[Category: Graham MA]]
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[[Category: Guichard, S]]
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[[Category: Guichard S]]
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[[Category: Hudson, K]]
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[[Category: Hudson K]]
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[[Category: Kettle, J G]]
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[[Category: Kettle JG]]
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[[Category: Mahmood, A]]
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[[Category: Mahmood A]]
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[[Category: Vincent, J]]
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[[Category: Vincent J]]
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[[Category: Ward, R A]]
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[[Category: Ward RA]]
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[[Category: Whittaker, D]]
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[[Category: Whittaker D]]
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[[Category: Oncology]]
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[[Category: Transferase]]
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Revision as of 07:44, 14 September 2022

Human TTK in complex with a Dyrk1B inhibitor

PDB ID 4d2s

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