4d4w
From Proteopedia
(Difference between revisions)
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==Solution structure of human MBD1 CXXC1 domain== | ==Solution structure of human MBD1 CXXC1 domain== | ||
| - | <StructureSection load='4d4w' size='340' side='right'caption='[[4d4w | + | <StructureSection load='4d4w' size='340' side='right'caption='[[4d4w]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4d4w]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4d4w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D4W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D4W FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d4w OCA], [https://pdbe.org/4d4w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d4w RCSB], [https://www.ebi.ac.uk/pdbsum/4d4w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d4w ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/MBD1_HUMAN MBD1_HUMAN]] Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.<ref>PMID:9207790</ref> <ref>PMID:10454587</ref> <ref>PMID:9774669</ref> <ref>PMID:10648624</ref> <ref>PMID:12711603</ref> <ref>PMID:12665582</ref> <ref>PMID:12697822</ref> <ref>PMID:14610093</ref> <ref>PMID:15327775</ref> <ref>PMID:14555760</ref> |
==See Also== | ==See Also== | ||
| - | *[[Methyl CpG binding protein|Methyl CpG binding protein]] | + | *[[Methyl CpG binding protein 3D structures|Methyl CpG binding protein 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Smith | + | [[Category: Smith BO]] |
| - | [[Category: Thomson | + | [[Category: Thomson R]] |
| - | + | ||
Current revision
Solution structure of human MBD1 CXXC1 domain
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