4d52
From Proteopedia
(Difference between revisions)
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<StructureSection load='4d52' size='340' side='right'caption='[[4d52]], [[Resolution|resolution]] 1.76Å' scene=''> | <StructureSection load='4d52' size='340' side='right'caption='[[4d52]], [[Resolution|resolution]] 1.76Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[4d52]] is a 4 chain structure. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4uq7 4uq7] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ahb 4ahb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D52 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4d52]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4uq7 4uq7] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ahb 4ahb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D52 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D52 FirstGlance]. <br> |
- | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GIV:BETA-L-GALACTOPYRANOSE'>GIV</scene>, <scene name='pdbligand=GXL:ALPHA-L-GALACTOPYRANOSE'>GXL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=GIV:BETA-L-GALACTOPYRANOSE'>GIV</scene>, <scene name='pdbligand=GXL:ALPHA-L-GALACTOPYRANOSE'>GXL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
- | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d52 OCA], [https://pdbe.org/4d52 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d52 RCSB], [https://www.ebi.ac.uk/pdbsum/4d52 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d52 ProSAT]</span></td></tr> | |
- | + | ||
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
+ | == Function == | ||
+ | [[https://www.uniprot.org/uniprot/LECF_ASPFU LECF_ASPFU]] Multispecific lectin that is able to recognize L-fucose in all possible linkages (PubMed:23695231, PubMed:27058347, PubMed:24340081, PubMed:25760594). These could be found not only in decomposed plant matter in soil, which is the natural environment for A.fumigatus, but also in various epitopes on human tissues (PubMed:25760594). Mediates binding of A.fumigatus conidia to airway mucinin a fucose dependent manner (PubMed:27058347). Stimulates IL-8 production by human bronchial cells in a dose-dependent manner, contributing to the inflammatory response observed upon the exposure of a patient to A.fumigatus, and thus might be an important virulence factor involved in an early stage of A.fumigatus infection (PubMed:24340081).<ref>PMID:23695231</ref> <ref>PMID:24340081</ref> <ref>PMID:25760594</ref> <ref>PMID:27058347</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
+ | [[Category: Aspergillus fumigatus]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
- | [[Category: Cioci | + | [[Category: Cioci G]] |
- | [[Category: Houser | + | [[Category: Houser J]] |
- | [[Category: Imberty | + | [[Category: Imberty A]] |
- | [[Category: Komarek | + | [[Category: Komarek J]] |
- | [[Category: Kostlanova | + | [[Category: Kostlanova N]] |
- | [[Category: Lahmann | + | [[Category: Lahmann M]] |
- | [[Category: Varrot | + | [[Category: Varrot A]] |
- | [[Category: Wimmerowa | + | [[Category: Wimmerowa M]] |
- | + |
Revision as of 07:47, 14 September 2022
CRYSTAL STRUCTURE OF FUCOSE BINDING LECTIN FROM ASPERGILLUS FUMIGATUS (AFL) IN COMPLEX WITH L-GALACTOPYRANOSE.
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