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4d60

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<StructureSection load='4d60' size='340' side='right'caption='[[4d60]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
<StructureSection load='4d60' size='340' side='right'caption='[[4d60]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4d60]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D60 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4d60]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D60 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d60 OCA], [http://pdbe.org/4d60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d60 RCSB], [http://www.ebi.ac.uk/pdbsum/4d60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d60 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d60 OCA], [https://pdbe.org/4d60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d60 RCSB], [https://www.ebi.ac.uk/pdbsum/4d60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d60 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PROF_PLAFX PROF_PLAFX]] Essential for the invasive blood stages of the parasite. Binds to proline rich sequences in various regulatory formin-like proteins and also to membrane phospholipids. Binds to actin and affects the structure of the cytoskeleton. Weakly sequesters actin monomers.<ref>PMID:19000816</ref>
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[[https://www.uniprot.org/uniprot/PROF_PLAF7 PROF_PLAF7]] Essential for the invasive blood stages of the parasite. Binds to proline rich sequences in various regulatory formin-like proteins and also to membrane phospholipids. Binds to actin and affects the structure of the cytoskeleton. Weakly sequesters actin monomers (By similarity).[UniProtKB:P86294]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Plafa]]
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[[Category: Plasmodium falciparum]]
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[[Category: Bhargav, S P]]
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[[Category: Bhargav SP]]
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[[Category: Kallio, J P]]
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[[Category: Kallio JP]]
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[[Category: Kursula, I]]
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[[Category: Kursula I]]
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[[Category: Kursula, P]]
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[[Category: Kursula P]]
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[[Category: Torda, A]]
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[[Category: Torda A]]
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[[Category: Vahokoski, J]]
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[[Category: Vahokoski J]]
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[[Category: Actin binding]]
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[[Category: Domain swapping]]
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[[Category: Structural protein]]
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Revision as of 07:48, 14 September 2022

Structure of a dimeric Plasmodium falciparum profilin mutant

PDB ID 4d60

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OCA

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