4d6r

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<StructureSection load='4d6r' size='340' side='right'caption='[[4d6r]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
<StructureSection load='4d6r' size='340' side='right'caption='[[4d6r]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4d6r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D6R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D6R FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4d6r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D6R FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IEJ:O-TOLUENESULFONAMIDE'>IEJ</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IEJ:O-TOLUENESULFONAMIDE'>IEJ</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4d6q|4d6q]], [[4d6s|4d6s]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d6r OCA], [https://pdbe.org/4d6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d6r RCSB], [https://www.ebi.ac.uk/pdbsum/4d6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d6r ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d6r OCA], [http://pdbe.org/4d6r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d6r RCSB], [http://www.ebi.ac.uk/pdbsum/4d6r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d6r ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KDM4D_HUMAN KDM4D_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref>
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[[https://www.uniprot.org/uniprot/KDM4D_HUMAN KDM4D_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Bradley, A]]
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[[Category: Bradley A]]
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[[Category: Burgess-Brown, N]]
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[[Category: Burgess-Brown N]]
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[[Category: Crawley, L]]
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[[Category: Crawley L]]
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[[Category: Delft, F von]]
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[[Category: Edwards A]]
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[[Category: Edwards, A]]
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[[Category: Gileadi C]]
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[[Category: Gileadi, C]]
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[[Category: Johansson C]]
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[[Category: Johansson, C]]
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[[Category: Krojer T]]
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[[Category: Krojer, T]]
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[[Category: Oppermann U]]
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[[Category: Oppermann, U]]
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[[Category: Szykowska A]]
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[[Category: Szykowska, A]]
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[[Category: Vollmar M]]
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[[Category: Vollmar, M]]
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[[Category: Von Delft F]]
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[[Category: Demethylase/2og]]
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[[Category: Flj10251]]
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[[Category: Jumonji domain containing 2d]]
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[[Category: Kdm4d]]
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[[Category: Mgc141909]]
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[[Category: Transcription]]
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Revision as of 07:49, 14 September 2022

crystal structure of human JMJD2D in complex with N-OXALYLGLYCINE and bound o-toluenesulfonamide

PDB ID 4d6r

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