1ifa

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[[Image:1ifa.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1ifa", creates the "Structure Box" on the page.
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{{STRUCTURE_1ifa| PDB=1ifa | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ifa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ifa OCA], [http://www.ebi.ac.uk/pdbsum/1ifa PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ifa RCSB]</span>
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'''THREE-DIMENSIONAL CRYSTAL STRUCTURE OF RECOMBINANT MURINE INTERFERON-BETA'''
'''THREE-DIMENSIONAL CRYSTAL STRUCTURE OF RECOMBINANT MURINE INTERFERON-BETA'''
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[[Category: Senda, T.]]
[[Category: Senda, T.]]
[[Category: Shimizu, H.]]
[[Category: Shimizu, H.]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:56:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:19:00 2008''
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Revision as of 16:56, 2 May 2008

Image:1ifa.jpg

Template:STRUCTURE 1ifa

THREE-DIMENSIONAL CRYSTAL STRUCTURE OF RECOMBINANT MURINE INTERFERON-BETA


Overview

The crystal structure of recombinant murine interferon-beta (IFN-beta) has been solved by the multiple isomorphous replacement method and refined to an R-factor of 20.5% against 2.6 A X-ray diffraction data. The structure shows a variant of the alpha-helix bundle with a new chain-folding topology, which seems to represent a basic structural framework of all the IFN-alpha and IFN-beta molecules belonging to the type I family. Functionally important segments of the polypeptide chain, as implied through numerous gene manipulation studies carried out so far, are spatially clustered indicating the binding site(s) to the receptor(s). Comparison of the present structure with those of other alpha-helical cytokine proteins, including porcine growth hormone, interleukin 2 and interferon gamma, indicated either a topological similarity in chain folding or a similar spatial arrangement of the alpha-helices.

About this Structure

1IFA is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Three-dimensional crystal structure of recombinant murine interferon-beta., Senda T, Shimazu T, Matsuda S, Kawano G, Shimizu H, Nakamura KT, Mitsui Y, EMBO J. 1992 Sep;11(9):3193-201. PMID:1505514 Page seeded by OCA on Fri May 2 19:56:27 2008

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