7use

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'''Unreleased structure'''
 
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The entry 7use is ON HOLD until Paper Publication
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==Cryo-EM structure of WAVE regulatory complex with Rac1 bound on both A and D site==
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<StructureSection load='7use' size='340' side='right'caption='[[7use]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7use]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7USE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7USE FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7use FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7use OCA], [https://pdbe.org/7use PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7use RCSB], [https://www.ebi.ac.uk/pdbsum/7use PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7use ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[https://www.uniprot.org/uniprot/CYFP1_HUMAN CYFP1_HUMAN]] Angelman syndrome.
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== Function ==
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[[https://www.uniprot.org/uniprot/CYFP1_HUMAN CYFP1_HUMAN]] Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.<ref>PMID:9417078</ref> <ref>PMID:16260607</ref> <ref>PMID:19524508</ref> <ref>PMID:21107423</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Chen B]]
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[[Category: Chowdhury S]]
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[[Category: Ding B]]
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[[Category: Yang S]]

Revision as of 07:39, 21 September 2022

Cryo-EM structure of WAVE regulatory complex with Rac1 bound on both A and D site

PDB ID 7use

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