7wwq
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human Ufd1-Npl4 complex== | |
| - | + | <StructureSection load='7wwq' size='340' side='right'caption='[[7wwq]], [[Resolution|resolution]] 2.72Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7wwq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WWQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WWQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wwq OCA], [https://pdbe.org/7wwq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wwq RCSB], [https://www.ebi.ac.uk/pdbsum/7wwq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wwq ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/NPL4_HUMAN NPL4_HUMAN]] The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729).[UniProtKB:Q9ES54]<ref>PMID:26471729</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Han BW]] | ||
| + | [[Category: Kang W]] | ||
| + | [[Category: Kim DH]] | ||
| + | [[Category: Kim HS]] | ||
| + | [[Category: Ko KS]] | ||
| + | [[Category: Le LTM]] | ||
| + | [[Category: Lee HT]] | ||
| + | [[Category: Nguyen TQ]] | ||
| + | [[Category: Nguyen YTK]] | ||
| + | [[Category: Yang JK]] | ||
Revision as of 07:41, 21 September 2022
Crystal structure of human Ufd1-Npl4 complex
| |||||||||||
Categories: Homo sapiens | Large Structures | Han BW | Kang W | Kim DH | Kim HS | Ko KS | Le LTM | Lee HT | Nguyen TQ | Nguyen YTK | Yang JK
