7y3w
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of an questin oxidase (BTG13) from Cercospora sp. JNU001== | |
| + | <StructureSection load='7y3w' size='340' side='right'caption='[[7y3w]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7y3w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cercospora_sojina Cercospora sojina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y3W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y3W FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y3w OCA], [https://pdbe.org/7y3w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y3w RCSB], [https://www.ebi.ac.uk/pdbsum/7y3w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y3w ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | This study used light-mediated comparative transcriptomics to identify the biosynthetic gene cluster of beticolin 1 in Cercospora. It contains an anthraquinone moiety and an unusual halogenated xanthone moiety connected by a bicyclo[3.2.2]nonane. During elucidation of the biosynthetic pathway of beticolin 1, a novel non-heme iron oxygenase BTG13 responsible for anthraquinone ring cleavage was discovered. More importantly, the discovery of non-heme iron oxygenase BTG13 is well supported by experimental evidence: (i) crystal structure and the inductively coupled plasma mass spectrometry revealed that its reactive site is built by an atypical iron ion coordination, where the iron ion is uncommonly coordinated by four histidine residues, an unusual carboxylated-lysine (Kcx377) and water; (ii) Kcx377 is mediated by His58 and Thr299 to modulate the catalytic activity of BTG13. Therefore, we believed this study updates our knowledge of metalloenzymes. | ||
| - | + | Discovery of the Biosynthetic Pathway of Beticolin 1 Reveals a Novel Non-Heme Iron-Dependent Oxygenase for Anthraquinone Ring Cleavage.,Hou X, Xu H, Deng Z, Yan Y, Yuan Z, Liu X, Su Z, Yang S, Zhang Y, Rao Y Angew Chem Int Ed Engl. 2022 Sep 12;61(37):e202208772. doi:, 10.1002/anie.202208772. Epub 2022 Aug 4. PMID:35862137<ref>PMID:35862137</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 7y3w" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Cercospora sojina]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Fu K]] | ||
| + | [[Category: Hou XD]] | ||
| + | [[Category: Rao YJ]] | ||
Current revision
Crystal structure of an questin oxidase (BTG13) from Cercospora sp. JNU001
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