1gri

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(New page: 200px<br /> <applet load="1gri" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gri, resolution 3.1&Aring;" /> '''GRB2'''<br /> ==Ove...)
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Revision as of 15:01, 12 November 2007

Image:1gri.gif

1gri, resolution 3.1Å

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GRB2

Contents

Overview

The mammalian growth factor receptor-binding protein Grb2 is an adaptor, that mediates activation of guanine nucleotide exchange on Ras. Grb2 binds, to the receptor through its SH2 domain and to the carboxyl-terminal domain, of Son of sevenless through its two SH3 domains. It is thus a key element, in the signal transduction pathway. The crystal structure of Grb2 was, determined to 3.1 angstrom resolution. The asymmetric unit is composed of, an embedded dimer. The interlaced junctions between the SH2 and SH3, domains bring the two adjacent faces of the SH3 domains in van der Waals, contact but leave room for the binding of proline-rich peptides.

Disease

Known diseases associated with this structure: Central hypoventilation syndrome, congenital OMIM:[100790], Haddad syndrome OMIM:[100790]

About this Structure

1GRI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the mammalian Grb2 adaptor., Maignan S, Guilloteau JP, Fromage N, Arnoux B, Becquart J, Ducruix A, Science. 1995 Apr 14;268(5208):291-3. PMID:7716522

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