4df4

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==Crystal structure of the large fragment of DNA Polymerase I from Thermus aquaticus in a closed ternary complex with 7-(N-(10-hydroxydecanoyl)-aminopentinyl)-7-deaza-2 -dATP==
==Crystal structure of the large fragment of DNA Polymerase I from Thermus aquaticus in a closed ternary complex with 7-(N-(10-hydroxydecanoyl)-aminopentinyl)-7-deaza-2 -dATP==
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<StructureSection load='4df4' size='340' side='right' caption='[[4df4]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='4df4' size='340' side='right'caption='[[4df4]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4df4]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_25104 Atcc 25104]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DF4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DF4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4df4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DF4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0L3:7-{2-DEOXY-5-O-[(S)-HYDROXY{[(S)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}PHOSPHORYL]-BETA-D-ERYTHRO-PENTOFURANOSYL}-5-{5-[(10-HYDROXYDECANOYL)AMINO]PENT-1-YN-1-YL}-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE'>0L3</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0L3:7-{2-DEOXY-5-O-[(S)-HYDROXY{[(S)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}PHOSPHORYL]-BETA-D-ERYTHRO-PENTOFURANOSYL}-5-{5-[(10-HYDROXYDECANOYL)AMINO]PENT-1-YN-1-YL}-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE'>0L3</scene>, <scene name='pdbligand=DOC:2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE'>DOC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOC:2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE'>DOC</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4df4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4df4 OCA], [https://pdbe.org/4df4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4df4 RCSB], [https://www.ebi.ac.uk/pdbsum/4df4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4df4 ProSAT]</span></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ktq|3ktq]], [[3oju|3oju]], [[3ojs|3ojs]], [[3lwm|3lwm]], [[3lwl|3lwl]], [[3m8s|3m8s]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pol I, pol1, polA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271 ATCC 25104])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4df4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4df4 OCA], [http://pdbe.org/4df4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4df4 RCSB], [http://www.ebi.ac.uk/pdbsum/4df4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4df4 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/DPO1_THEAQ DPO1_THEAQ]]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4df4" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4df4" style="background-color:#fffaf0;"></div>
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==See Also==
 
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*[[DNA polymerase|DNA polymerase]]
 
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 25104]]
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[[Category: Large Structures]]
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Thermus aquaticus]]
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[[Category: Baccaro, A]]
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[[Category: Baccaro A]]
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[[Category: Bergen, K]]
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[[Category: Bergen K]]
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[[Category: Diederichs, K]]
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[[Category: Diederichs K]]
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[[Category: Marx, A]]
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[[Category: Marx A]]
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[[Category: Steck, A]]
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[[Category: Steck A]]
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[[Category: Struett, S]]
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[[Category: Struett S]]
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[[Category: Welte, W]]
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[[Category: Welte W]]
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[[Category: Dna polymerase]]
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[[Category: Transferase-dna complex]]
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Revision as of 08:15, 21 September 2022

Crystal structure of the large fragment of DNA Polymerase I from Thermus aquaticus in a closed ternary complex with 7-(N-(10-hydroxydecanoyl)-aminopentinyl)-7-deaza-2 -dATP

PDB ID 4df4

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OCA

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