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4dfu

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==Inhibition of an antibiotic resistance enzyme: crystal structure of aminoglycoside phosphotransferase APH(2")-ID/APH(2")-IVA in complex with kanamycin inhibited with quercetin==
==Inhibition of an antibiotic resistance enzyme: crystal structure of aminoglycoside phosphotransferase APH(2")-ID/APH(2")-IVA in complex with kanamycin inhibited with quercetin==
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<StructureSection load='4dfu' size='340' side='right' caption='[[4dfu]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
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<StructureSection load='4dfu' size='340' side='right'caption='[[4dfu]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4dfu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"streptococcus_casseliflavus"_vaughan_et_al._1979 "streptococcus casseliflavus" vaughan et al. 1979]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3vcq 3vcq] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r82 3r82]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DFU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4dfu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3vcq 3vcq] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r82 3r82]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DFU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KAN:KANAMYCIN+A'>KAN</scene>, <scene name='pdbligand=QUE:3,5,7,3,4-PENTAHYDROXYFLAVONE'>QUE</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KAN:KANAMYCIN+A'>KAN</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=QUE:3,5,7,3,4-PENTAHYDROXYFLAVONE'>QUE</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dfu OCA], [https://pdbe.org/4dfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dfu RCSB], [https://www.ebi.ac.uk/pdbsum/4dfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dfu ProSAT]</span></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4dbx|4dbx]], [[4de4|4de4]], [[4dfb|4dfb]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">APH(2")-Id ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37734 "Streptococcus casseliflavus" Vaughan et al. 1979])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dfu OCA], [http://pdbe.org/4dfu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dfu RCSB], [http://www.ebi.ac.uk/pdbsum/4dfu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dfu ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/O68183_ENTCA O68183_ENTCA]]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Phosphotransferase|Phosphotransferase]]
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*[[Phosphotransferase 3D structures|Phosphotransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Streptococcus casseliflavus vaughan et al. 1979]]
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[[Category: Enterococcus casseliflavus]]
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[[Category: Anderson, W F]]
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[[Category: Large Structures]]
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[[Category: Structural genomic]]
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[[Category: Anderson WF]]
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[[Category: Dong, A]]
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[[Category: Di Leo R]]
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[[Category: Egorova, E]]
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[[Category: Dong A]]
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[[Category: Evdokimova, E]]
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[[Category: Egorova E]]
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[[Category: Leo, R Di]]
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[[Category: Evdokimova E]]
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[[Category: Li, H]]
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[[Category: Li H]]
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[[Category: Minasov, G]]
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[[Category: Minasov G]]
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[[Category: Savchenko, A]]
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[[Category: Savchenko A]]
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[[Category: Shakya, T]]
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[[Category: Shakya T]]
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[[Category: Stogios, P J]]
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[[Category: Stogios PJ]]
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[[Category: Wright, G D]]
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[[Category: Wright GD]]
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[[Category: Aminoglycoside phosphotransferase]]
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[[Category: Aminoglycoside]]
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[[Category: Antibotic]]
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[[Category: Csgid]]
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[[Category: Eukaryotic protein kinase-like fold]]
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[[Category: Flavanoid]]
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[[Category: Intracellular]]
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[[Category: Kanamycin]]
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[[Category: Kinase]]
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[[Category: Quercetin]]
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[[Category: Transferase]]
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[[Category: Transferase-antibiotic-inhibitor complex]]
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[[Category: Transferase-antibotic-inhibitor complex]]
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Revision as of 08:16, 21 September 2022

Inhibition of an antibiotic resistance enzyme: crystal structure of aminoglycoside phosphotransferase APH(2")-ID/APH(2")-IVA in complex with kanamycin inhibited with quercetin

PDB ID 4dfu

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