4dhr
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening== | ==Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening== | ||
| - | <StructureSection load='4dhr' size='340' side='right' caption='[[4dhr]], [[Resolution|resolution]] 1.40Å' scene=''> | + | <StructureSection load='4dhr' size='340' side='right'caption='[[4dhr]], [[Resolution|resolution]] 1.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4dhr]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4dhr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DHR FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=Y04:(2-{2-[(2-CHLOROPHENYL)AMINO]-2-OXOETHOXY}PHENYL)PHOSPHONIC+ACID'>Y04</scene> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=Y04:(2-{2-[(2-CHLOROPHENYL)AMINO]-2-OXOETHOXY}PHENYL)PHOSPHONIC+ACID'>Y04</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dhr OCA], [https://pdbe.org/4dhr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dhr RCSB], [https://www.ebi.ac.uk/pdbsum/4dhr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dhr ProSAT]</span></td></tr> | |
| - | + | ||
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression. |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 23: | Line 20: | ||
==See Also== | ==See Also== | ||
| - | *[[14-3-3 protein|14-3-3 protein]] | + | *[[14-3-3 protein 3D structures|14-3-3 protein 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Kohlbacher | + | [[Category: Large Structures]] |
| - | [[Category: Ottmann | + | [[Category: Kohlbacher O]] |
| - | [[Category: Roeglin | + | [[Category: Ottmann C]] |
| - | [[Category: Thiel | + | [[Category: Roeglin L]] |
| - | + | [[Category: Thiel P]] | |
| - | + | ||
| - | + | ||
Revision as of 08:18, 21 September 2022
Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening
| |||||||||||
