4drk

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==EVALUATION OF SYNTHETIC FK506 ANALOGS AS LIGANDS FOR FKBP51 AND FKBP52: COMPLEX OF FKBP51 WITH {3-[(1R)-3-(3,4-dimethoxyphenyl)-1-({[(2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidin-2-yl]carbonyl}oxy)propyl]phenoxy}acetic acid==
==EVALUATION OF SYNTHETIC FK506 ANALOGS AS LIGANDS FOR FKBP51 AND FKBP52: COMPLEX OF FKBP51 WITH {3-[(1R)-3-(3,4-dimethoxyphenyl)-1-({[(2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidin-2-yl]carbonyl}oxy)propyl]phenoxy}acetic acid==
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<StructureSection load='4drk' size='340' side='right' caption='[[4drk]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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<StructureSection load='4drk' size='340' side='right'caption='[[4drk]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4drk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DRK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DRK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4drk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DRK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DRK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I63:{3-[(1R)-3-(3,4-DIMETHOXYPHENYL)-1-({[(2S)-1-(3,3-DIMETHYL-2-OXOPENTANOYL)PIPERIDIN-2-YL]CARBONYL}OXY)PROPYL]PHENOXY}ACETIC+ACID'>I63</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I63:{3-[(1R)-3-(3,4-DIMETHOXYPHENYL)-1-({[(2S)-1-(3,3-DIMETHYL-2-OXOPENTANOYL)PIPERIDIN-2-YL]CARBONYL}OXY)PROPYL]PHENOXY}ACETIC+ACID'>I63</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4drm|4drm]], [[4drn|4drn]], [[4dro|4dro]], [[4drp|4drp]], [[4drq|4drq]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4drk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4drk OCA], [https://pdbe.org/4drk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4drk RCSB], [https://www.ebi.ac.uk/pdbsum/4drk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4drk ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AIG6, FKBP5, FKBP51 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4drk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4drk OCA], [http://pdbe.org/4drk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4drk RCSB], [http://www.ebi.ac.uk/pdbsum/4drk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4drk ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FKBP5_HUMAN FKBP5_HUMAN]] Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
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[[https://www.uniprot.org/uniprot/FKBP5_HUMAN FKBP5_HUMAN]] Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[FK506 binding protein|FK506 binding protein]]
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*[[FKBP 3D structures|FKBP 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Large Structures]]
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[[Category: Bracher, A]]
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[[Category: Bracher A]]
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[[Category: Gaali, S]]
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[[Category: Gaali S]]
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[[Category: Gopalakrishnan, R]]
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[[Category: Gopalakrishnan R]]
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[[Category: Hausch, F]]
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[[Category: Hausch F]]
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[[Category: Hoogeland, B]]
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[[Category: Hoogeland B]]
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[[Category: Kozany, C]]
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[[Category: Kozany C]]
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[[Category: Kress, C]]
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[[Category: Kress C]]
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[[Category: Fk-506 binding domain]]
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[[Category: Hsp90 cochaperone]]
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[[Category: Immunophilin]]
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[[Category: Isomerase]]
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[[Category: Peptidyl-prolyl isomerase]]
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Revision as of 08:35, 21 September 2022

EVALUATION OF SYNTHETIC FK506 ANALOGS AS LIGANDS FOR FKBP51 AND FKBP52: COMPLEX OF FKBP51 WITH {3-[(1R)-3-(3,4-dimethoxyphenyl)-1-({[(2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidin-2-yl]carbonyl}oxy)propyl]phenoxy}acetic acid

PDB ID 4drk

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