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4dxj

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==Crystal structure of Trypanosome cruzi farnesyl diphosphate synthase in complex with [2-(n-propylamino)ethane-1,1-diyl]bisphosphonic acid and Mg2+==
==Crystal structure of Trypanosome cruzi farnesyl diphosphate synthase in complex with [2-(n-propylamino)ethane-1,1-diyl]bisphosphonic acid and Mg2+==
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<StructureSection load='4dxj' size='340' side='right' caption='[[4dxj]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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<StructureSection load='4dxj' size='340' side='right'caption='[[4dxj]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4dxj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DXJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DXJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4dxj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DXJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0M9:[2-(PROPYLAMINO)ETHANE-1,1-DIYL]BIS(PHOSPHONIC+ACID)'>0M9</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=IPE:3-METHYLBUT-3-ENYL+TRIHYDROGEN+DIPHOSPHATE'>IPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0M9:[2-(PROPYLAMINO)ETHANE-1,1-DIYL]BIS(PHOSPHONIC+ACID)'>0M9</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=IPE:3-METHYLBUT-3-ENYL+TRIHYDROGEN+DIPHOSPHATE'>IPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1yhk|1yhk]], [[1yhl|1yhl]], [[1yhm|1yhm]], [[3iba|3iba]], [[3ick|3ick]], [[3icm|3icm]], [[3icn|3icn]], [[3icz|3icz]], [[4dwb|4dwb]], [[4dwg|4dwg]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dxj OCA], [https://pdbe.org/4dxj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dxj RCSB], [https://www.ebi.ac.uk/pdbsum/4dxj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dxj ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FPPS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 TRYCR])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(2E,6E)-farnesyl_diphosphate_synthase (2E,6E)-farnesyl diphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.10 2.5.1.10] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dxj OCA], [http://pdbe.org/4dxj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dxj RCSB], [http://www.ebi.ac.uk/pdbsum/4dxj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dxj ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/Q95WL3_TRYCR Q95WL3_TRYCR]]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Farnesyl diphosphate synthase|Farnesyl diphosphate synthase]]
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*[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Trycr]]
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[[Category: Large Structures]]
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[[Category: Amzel, L M]]
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[[Category: Trypanosoma cruzi]]
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[[Category: Aripirala, S]]
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[[Category: Amzel LM]]
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[[Category: Gabelli, S B]]
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[[Category: Aripirala S]]
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[[Category: Geranyl transferase]]
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[[Category: Gabelli SB]]
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[[Category: Transferase-transferase inhibitor complex]]
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Revision as of 08:42, 21 September 2022

Crystal structure of Trypanosome cruzi farnesyl diphosphate synthase in complex with [2-(n-propylamino)ethane-1,1-diyl]bisphosphonic acid and Mg2+

PDB ID 4dxj

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