7v6o
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==MERS S ectodomain trimer in complex with neutralizing antibody 111 (state 2)== | |
| - | + | <StructureSection load='7v6o' size='340' side='right'caption='[[7v6o]], [[Resolution|resolution]] 4.56Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7v6o]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_betacoronavirus_2c_EMC/2012 Human betacoronavirus 2c EMC/2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7V6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7V6O FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v6o OCA], [https://pdbe.org/7v6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v6o RCSB], [https://www.ebi.ac.uk/pdbsum/7v6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v6o ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/K0BRG7_MERS K0BRG7_MERS]] Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.[HAMAP-Rule:MF_04099] Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099] Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Human betacoronavirus 2c EMC/2012]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Wang X]] | ||
| + | [[Category: Wang Y]] | ||
| + | [[Category: Wang Z]] | ||
| + | [[Category: Zeng J]] | ||
| + | [[Category: Zhang S]] | ||
| + | [[Category: Zhao J]] | ||
Revision as of 06:17, 28 September 2022
MERS S ectodomain trimer in complex with neutralizing antibody 111 (state 2)
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