7vh9
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of the chimeric peptide of the first SURP domain of Human SF3A1 and the interacting region of SF1.== | |
| - | + | <StructureSection load='7vh9' size='340' side='right'caption='[[7vh9]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7vh9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VH9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VH9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vh9 OCA], [https://pdbe.org/7vh9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vh9 RCSB], [https://www.ebi.ac.uk/pdbsum/7vh9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vh9 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/SF3A1_HUMAN SF3A1_HUMAN]] Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.[[https://www.uniprot.org/uniprot/SF01_HUMAN SF01_HUMAN]] Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.<ref>PMID:8752089</ref> <ref>PMID:10449420</ref> <ref>PMID:9660765</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kobayashi N]] | ||
| + | [[Category: Kuwasako K]] | ||
| + | [[Category: Muto Y]] | ||
| + | [[Category: Sakamoto T]] | ||
| + | [[Category: Takizawa M]] | ||
Revision as of 06:18, 28 September 2022
Solution structure of the chimeric peptide of the first SURP domain of Human SF3A1 and the interacting region of SF1.
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