1ij9

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[[Image:1ij9.jpg|left|200px]]
[[Image:1ij9.jpg|left|200px]]
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{{Structure
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{{STRUCTURE_1ij9| PDB=1ij9 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ij9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ij9 OCA], [http://www.ebi.ac.uk/pdbsum/1ij9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ij9 RCSB]</span>
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'''Highly Hydrated Human VCAM-1 Fragment'''
'''Highly Hydrated Human VCAM-1 Fragment'''
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[[Category: Taylor, P.]]
[[Category: Taylor, P.]]
[[Category: Walkinshaw, M D.]]
[[Category: Walkinshaw, M D.]]
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[[Category: integrin solvation]]
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[[Category: Integrin solvation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:03:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:20:38 2008''
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Revision as of 17:03, 2 May 2008

Image:1ij9.jpg

Template:STRUCTURE 1ij9

Highly Hydrated Human VCAM-1 Fragment


Overview

An X-ray crystal structure of two N-terminal integrin-binding IgSF domains of human VCAM-1 is reported. This new crystal form shows an unusual and highly hydrated packing arrangement in which over 80% of the crystal is occupied by solvent. The relative orientations of the two domains adopt a new intermediate conformation. The tilt angle between the two domains is 19.4 degrees, compared with other related structures that have tilt angles ranging from 7.3 to 39.9 degrees. An analysis of the torsion angles shows that residues Ile88, Tyr89, Ser90, Pro92 and Glu96 play a major role in defining the interdomain conformations.

About this Structure

1IJ9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A new conformation of the integrin-binding fragment of human VCAM-1 crystallizes in a highly hydrated packing arrangement., Taylor P, Bilsland M, Walkinshaw MD, Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt 11):1579-83. Epub 2001, Oct 25. PMID:11679722 Page seeded by OCA on Fri May 2 20:03:44 2008

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