1ijr

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[[Image:1ijr.jpg|left|200px]]
[[Image:1ijr.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1ijr |SIZE=350|CAPTION= <scene name='initialview01'>1ijr</scene>, resolution 2.2&Aring;
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The line below this paragraph, containing "STRUCTURE_1ijr", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CC0:(4-{2-ACETYLAMINO-2-[1-(3-CARBAMOYL-4-CYCLOHEXYLMETHOXY-PHENYL)-ETHYLCARBAMOYL}-ETHYL}-2-PHOSPHONO-PHENOXY)-ACETIC+ACID'>CC0</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1ijr| PDB=1ijr | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ijr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ijr OCA], [http://www.ebi.ac.uk/pdbsum/1ijr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ijr RCSB]</span>
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}}
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'''Crystal structure of LCK SH2 complexed with nonpeptide phosphotyrosine mimetic'''
'''Crystal structure of LCK SH2 complexed with nonpeptide phosphotyrosine mimetic'''
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[[Category: Sundaramoorthi, R.]]
[[Category: Sundaramoorthi, R.]]
[[Category: Yang, M H.]]
[[Category: Yang, M H.]]
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[[Category: tyrosine-protein kinase]]
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[[Category: Tyrosine-protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:04:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:20:43 2008''
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Revision as of 17:04, 2 May 2008

Image:1ijr.jpg

Template:STRUCTURE 1ijr

Crystal structure of LCK SH2 complexed with nonpeptide phosphotyrosine mimetic


Overview

The novel phosphotyrosine (pTyr) mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp) has been designed and incorporated into a series of nonpeptide inhibitors of the SH2 domain of pp60(c-Src) (Src) tyrosine kinase. A 2.2 A X-ray crystal structure of 1a bound to a mutant form of Lck SH2 domain provides insight regarding the structure-activity relationships and supports the design concept of this new pTyr mimetic.

About this Structure

1IJR is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain., Kawahata N, Yang MG, Luke GP, Shakespeare WC, Sundaramoorthi R, Wang Y, Johnson D, Merry T, Violette S, Guan W, Bartlett C, Smith J, Hatada M, Lu X, Dalgarno DC, Eyermann CJ, Bohacek RS, Sawyer TK, Bioorg Med Chem Lett. 2001 Sep 3;11(17):2319-23. PMID:11527723 Page seeded by OCA on Fri May 2 20:04:37 2008

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OCA

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