4eaq

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==Crystal structure of Thymidylate Kinase from Staphylococcus aureus in complex with 3'-Azido-3'-Deoxythymidine-5'-Monophosphate==
==Crystal structure of Thymidylate Kinase from Staphylococcus aureus in complex with 3'-Azido-3'-Deoxythymidine-5'-Monophosphate==
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<StructureSection load='4eaq' size='340' side='right' caption='[[4eaq]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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<StructureSection load='4eaq' size='340' side='right'caption='[[4eaq]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4eaq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staam Staam]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EAQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EAQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4eaq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EAQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EAQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATM:3-AZIDO-3-DEOXYTHYMIDINE-5-MONOPHOSPHATE'>ATM</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATM:3-AZIDO-3-DEOXYTHYMIDINE-5-MONOPHOSPHATE'>ATM</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4dwj|4dwj]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eaq OCA], [https://pdbe.org/4eaq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eaq RCSB], [https://www.ebi.ac.uk/pdbsum/4eaq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eaq ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tmk, SAV0482 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158878 STAAM])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eaq OCA], [http://pdbe.org/4eaq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4eaq RCSB], [http://www.ebi.ac.uk/pdbsum/4eaq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4eaq ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KTHY_STAAM KTHY_STAAM]] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity).
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[[https://www.uniprot.org/uniprot/KTHY_STAAM KTHY_STAAM]] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity).
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==See Also==
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*[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Staam]]
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[[Category: Large Structures]]
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[[Category: DTMP kinase]]
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[[Category: Staphylococcus aureus subsp. aureus Mu50]]
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[[Category: Anderson, W F]]
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[[Category: Anderson WF]]
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[[Category: Babnigg, G]]
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[[Category: Babnigg G]]
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[[Category: Filippova, E V]]
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[[Category: Filippova EV]]
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[[Category: Jedrzejczak, R]]
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[[Category: Jedrzejczak R]]
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[[Category: Joachimiak, A]]
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[[Category: Joachimiak A]]
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[[Category: Kiryukhina, O]]
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[[Category: Kiryukhina O]]
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[[Category: Structural genomic]]
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[[Category: Minasov G]]
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[[Category: MTBI, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors]]
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[[Category: Rubin E]]
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[[Category: Minasov, G]]
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[[Category: Sacchettini J]]
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[[Category: Rubin, E]]
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[[Category: Shuvalova L]]
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[[Category: Sacchettini, J]]
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[[Category: Shuvalova, L]]
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[[Category: Mcsg]]
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[[Category: Mtbi]]
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[[Category: Psi-biology]]
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[[Category: Structures of mtb proteins conferring susceptibility to known mtb inhibitor]]
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[[Category: Thymidylate kinase]]
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[[Category: Transferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Revision as of 07:00, 28 September 2022

Crystal structure of Thymidylate Kinase from Staphylococcus aureus in complex with 3'-Azido-3'-Deoxythymidine-5'-Monophosphate

PDB ID 4eaq

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