This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ik3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1ik3.jpg|left|200px]]
[[Image:1ik3.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1ik3 |SIZE=350|CAPTION= <scene name='initialview01'>1ik3</scene>, resolution 2.0&Aring;
+
The line below this paragraph, containing "STRUCTURE_1ik3", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=FE3:Fe+(Fe+3)+Active+Site'>FE3</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=11O:(TRANS-12,13-EPOXY)-11-HYDROXY-9(Z)-OCTADECENOIC+ACID'>11O</scene>, <scene name='pdbligand=13R:13(R)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC+ACID'>13R</scene>, <scene name='pdbligand=13S:13(S)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC+ACID'>13S</scene>, <scene name='pdbligand=9OH:(TRANS-12,13-EPOXY)-9-HYDROXY-10(E)-OCTADECENOIC+ACID'>9OH</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Lipoxygenase Lipoxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.12 1.13.11.12] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1ik3| PDB=1ik3 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ik3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ik3 OCA], [http://www.ebi.ac.uk/pdbsum/1ik3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ik3 RCSB]</span>
+
-
}}
+
'''LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 13(S)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC ACID'''
'''LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 13(S)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC ACID'''
Line 28: Line 25:
[[Category: Jr., M O.Funk.]]
[[Category: Jr., M O.Funk.]]
[[Category: Skrzypczak-Jankun, E.]]
[[Category: Skrzypczak-Jankun, E.]]
-
[[Category: fe(iii) complex]]
+
[[Category: Interm]]
-
[[Category: interm]]
+
[[Category: Oxidoreductase]]
-
[[Category: oxidoreductase]]
+
[[Category: Purple lipoxygenase]]
-
[[Category: purple lipoxygenase]]
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:05:16 2008''
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:20:51 2008''
+

Revision as of 17:05, 2 May 2008

Image:1ik3.jpg

Template:STRUCTURE 1ik3

LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 13(S)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC ACID


Overview

Polyunsaturated fatty acid metabolism is governed primarily by two enzymes, prostaglandin H synthase and lipoxygenase. The crystal structure of the metastable product-oxidized purple form of soybean lipoxygenase-3 was determined at 2.0 A resolution. The data reveal that the chromophore corresponds to an iron-peroxide complex, a potential intermediate in the catalyzed reaction. A significant alteration of the iron site accompanies the formation of the complex. The structure, the first for a fatty acid-lipoxygenase complex, also reveals an unexpected mode of binding, and identifies amino acid residues that may play significant roles in catalysis, regio- and stereoselectivity.

About this Structure

1IK3 is a Single protein structure of sequence from Glycine max. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of a purple lipoxygenase., Skrzypczak-Jankun E, Bross RA, Carroll RT, Dunham WR, Funk MO Jr, J Am Chem Soc. 2001 Nov 7;123(44):10814-20. PMID:11686682 Page seeded by OCA on Fri May 2 20:05:16 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ik3"
Personal tools