4eje
From Proteopedia
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==Structure Of The Tsg101 UEV Domain In Complex With an Ebola PTAP late Domain Peptide== | ==Structure Of The Tsg101 UEV Domain In Complex With an Ebola PTAP late Domain Peptide== | ||
| - | <StructureSection load='4eje' size='340' side='right' caption='[[4eje]], [[Resolution|resolution]] 2.20Å' scene=''> | + | <StructureSection load='4eje' size='340' side='right'caption='[[4eje]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4eje]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4eje]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ebola_virus_-_Mayinga,_Zaire,_1976 Ebola virus - Mayinga, Zaire, 1976] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EJE FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eje OCA], [https://pdbe.org/4eje PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eje RCSB], [https://www.ebi.ac.uk/pdbsum/4eje PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eje ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/TS101_HUMAN TS101_HUMAN]] Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses.<ref>PMID:11916981</ref> <ref>PMID:17853893</ref> <ref>PMID:17556548</ref> |
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| + | ==See Also== | ||
| + | *[[Tumor susceptibility gene 101|Tumor susceptibility gene 101]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Ebola virus - Mayinga, Zaire, 1976]] |
| - | + | [[Category: Homo sapiens]] | |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Camara-Artigas A]] |
| - | [[Category: | + | |
Revision as of 07:13, 28 September 2022
Structure Of The Tsg101 UEV Domain In Complex With an Ebola PTAP late Domain Peptide
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